Influenza vaccination during the first 6 months after solid organ transplantation is efficacious and safe
| Autor: | Patricia Muñoz, J.L. Montero, M.A. Gentil-Govantes, Diego Rincón, José María Aguado, Jordi Carratalà, P. Diez, Julián Torre-Cisneros, Marino Blanes, Angel Bulnes-Ramos, Joan Gavaldà, Manuel Rodríguez, S. Fernández-Rozas, C. Berasategui, I. Morales-Barroso, R. Durán, M.C. Fariñas, Paula López-Roa, Marta Bodro, F. Anaya, Cristina Roca, Elisa Vidal, Magda Campins, A. Gasch, Manuel López-Meseguer, F. Zurbano-Goñi, Miguel Montejo, M. Cobo-Beláustegy, Magdalena Salcedo, Alia Eworo, Elisa Cordero, S. Oriol, J. Fortún, Sylvana Melo dos Santos, M. Valerio, A. Rodríguez, C. Rosso, Francisco López-Medrano, Pilar Pérez-Romero, Rosario Lara, Julia Origüen, Juliana Martinez-Atienza, M.L. Agüera, Jordi Niubó, Emilio Bouza, Martha Kestler, E. Fábrega-García, Josune Goikoetxea, Teresa Aydillo, A. Páez, J.M. Alamo, Fernando Casafont, Sara Cantisán, M. Peghin, N. Sabé, M. A. Marcos, E. Lage, Claudia González-Rico, Y. Sousa, F.J. Molina-Ortega, J.L. Barranco, G. Sanclemente, N. Diez, A. Moreno, M. Sánchez, Pilar Catalán, Berta Sáez, J.M. Arizón, Alejandro Suárez-Benjumea |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Microbiology (medical) medicine.medical_specialty Adolescent Drug-Related Side Effects and Adverse Reactions Influenza vaccine Disease Antibodies Viral seroprotection immune response Young Adult Influenza A Virus H1N1 Subtype Internal medicine Influenza Human medicine Humans Prospective Studies Adverse effect Prospective cohort study solid organ transplantation Immunization Schedule Aged Early vaccination Aged 80 and over business.industry Influenza A Virus H3N2 Subtype Immunogenicity Organ Transplantation General Medicine Middle Aged Transplant Recipients Confidence interval Surgery Vaccination Transplantation Influenza B virus Treatment Outcome Infectious Diseases Influenza Vaccines influenza vaccine business |
| Popis: | Preventing influenza infection early after transplantation is essential, given the disease's high mortality. A multicentre prospective cohort study in adult solid organ transplant recipients (SOTR) receiving the influenza vaccine during four consecutive influenza seasons (2009–2013) was performed to assess the immunogenicity and safety of influenza vaccination in SOTR before and 6 months after transplantation. A total of 798 SOTR, 130 of them vaccinated within 6 months of transplantation and 668 of them vaccinated more than 6 months since transplantation. Seroprotection was similar in both groups: 73.1% vs. 76.5% for A/(H1N1)pdm (p 0.49), 67.5% vs. 74.1% for A/H3N2 (p 0.17) and 84.2% vs. 85.2% for influenza B (p 0.80), respectively. Geometric mean titres after vaccination did not differ among groups: 117.32 (95% confidence interval (CI) 81.52, 168.83) vs. 87.43 (95% CI 72.87, 104.91) for A/(H1N1)pdm, 120.45 (95% CI 82.17, 176.57) vs. 97.86 (95% CI 81.34, 117.44) for A/H3N2 and 143.32 (95% CI 103.46, 198.53) vs. 145.54 (95% CI 122.35, 174.24) for influenza B, respectively. After adjusting for confounding factors, time since transplantation was not associated with response to vaccination. No cases of rejection or severe adverse events were detected in patients vaccinated within the first 6 months after transplantation. In conclusion, influenza vaccination within the first 6 months after transplantation is as safe and immunogenic as vaccination thereafter. Thus, administration of the influenza vaccine can be recommended as soon as 1 month after transplantation. |
| Databáze: | OpenAIRE |
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