Regulation by Ca2+in the Yersinia low-Ca2+response

Autor: Gregory V. Plano, Elźbieta Skrzypek, Pryce L. Haddix, Kenneth A. Fields, Susan C. Straley
Rok vydání: 1993
Předmět:
Zdroj: Molecular Microbiology. 8:1005-1010
ISSN: 1365-2958
0950-382X
DOI: 10.1111/j.1365-2958.1993.tb01644.x
Popis: The Yersinia low-Ca2+ response (LCR) is a regulatory response in which a set of plasmid-borne operons is transcriptionally regulated at 37 degrees C in response to the presence or absence of mM concentrations of Ca2+. LCR-regulated operons encode secreted proteins with regulatory and virulence roles as well as non-secreted regulatory proteins and components of the secretion machinery. Downregulation by Ca2+ is imposed by a signalling cascade that includes secreted proteins and possibly also components of the secretion system and is hypothesized to act on membrane-bound inductive components. An important role in LCR induction is played by LcrD, an inner-membrane protein with homologues in several virulence-associated and flagella assembly-related systems in diverse bacterial species. The mechanism of signal transduction in response to Ca2+ is not known, and the proteins that bind DNA to downregulate transcription have not been identified.
Databáze: OpenAIRE
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