Glomerular Refractoriness to Contractile Stimuli in Rabbits Recovering from Ischemic Acute Renal Failure
| Autor: | Mistumasa Nagase, Akira Hishida, Kazuhisa Ohishi, Katsuhiko Yonemura, Nishio Honda, Katsuhito Ikuma |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
business.industry Refractory period Angiotensin II Kidney Glomerulus Acute Kidney Injury Kidney Arginine Vasopressin Norepinephrine (medication) Norepinephrine Endocrinology Ischemia Internal medicine medicine Animals Vasoconstrictor Agents Rabbits business A determinant medicine.drug |
| Zdroj: | Nephron. 48:306-309 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | The present work was performed on uninephrectomized rabbits recovering from ischemic acute renal failure (ARF) in an attempt to elucidate whether or not intraglomerular events are a determinant factor in the development of resistance to ARF. 14 days after a 2-hour clamping of the renal artery (the recovery phase), the animals did not show resistance to an additional ischemia. On the other hand, glomeruli derived from normal kidneys displayed a contractile response to angiotensin II, arginine vasopressin or norepinephrine in Eagle's minimum essential medium, whereas glomeruli from rabbits recovering from ischemic ARF were refractory to the vasoconstrictor agents. The findings suggest that glomerular refractoriness to contractile stimuli does not provide resistance to an additional renal ischemia in the ischemic model of ARF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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