Effects of low-dose alcohol exposure in adolescence on subsequent alcohol drinking in adulthood in a rat model of depression
| Autor: | Petra Amchová, Yousef Tizabi, Filip Šiška, Jana Ruda-Kucerova, Daniela Kuruczova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Alcohol Drinking Rat model Alcohol Alcohol use disorder Alcohol exposure 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine mental disorders medicine Animals Rats Wistar Biological Psychiatry Depression (differential diagnoses) Ethanol business.industry Depression Low dose food and beverages medicine.disease 3. Good health 030227 psychiatry Rats Psychiatry and Mental health Alcoholism Endocrinology Mood chemistry NBQX business |
| Zdroj: | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 22(10) |
| ISSN: | 1814-1412 |
| Popis: | Adolescence drinking and subsequent development of alcohol use disorder (AUD) is a worldwide health concern. In particular, mood dysregulation or early alcohol exposure can be the cause of heavy drinking in some individuals or a consequence of heavy drinking in others.This study investigated the effects of voluntary alcohol intake during adolescence, i.e. continuous 10% alcohol access between postnatal days (PND) 29 to 43 and olfactory bulbectomy (OBX) model of depression (performed on PND 59) on alcohol drinking in Wistar rats during adulthood (PND 80-120, intermittent 20% alcohol access). In addition, the effect of NBQX, an AMPA/kainate receptor antagonist (5 mg/kg, IP) on spontaneous alcohol consumption was examined.Rats exposed to 10% alcohol during adolescence exhibited a lower 20% alcohol intake in the intermittent paradigm during adulthood, while the OBX-induced phenotype did not exert a significant effect on the drinking behaviour. NBQX exerted a transient reduction on alcohol intake in the OBX rats.Our results indicate that exposure to alcohol during adolescence can affect alcohol drinking in adulthood and that further exploration of AMPA and/or kainate receptor antagonists in co-morbid alcoholism-depression is warranted. |
| Databáze: | OpenAIRE |
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