Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue: assessment of adipogenesis and adipocyte glucose and lipid turnover

Autor: Tove Fall, Prasad G. Kamble, Erik Ingelsson, Maria J. Pereira, Jan W. Eriksson, Stefan Gustafsson, Casimiro Castillejo-López, Per Lundkvist
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Medicin och hälsovetenskap
Histology
Peroxisome proliferator-activated receptor
Adipose tissue
030209 endocrinology & metabolism
Type 2 diabetes
Medical and Health Sciences
Polymorphism
Single Nucleotide

PPARG Pro12Ala
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Adipocyte
Internal medicine
medicine
Adipocytes
Humans
Receptor
Cells
Cultured

human adipose tissue
Aged
chemistry.chemical_classification
Pro12ala polymorphism
Adipogenesis
Cell Biology
Peroxisome
Middle Aged
Protective Factors
medicine.disease
Lipid Metabolism
PPAR gamma
030104 developmental biology
Endocrinology
Glucose
chemistry
Adipose Tissue
Diabetes Mellitus
Type 2

Gene Expression Regulation
PPARγ Pro12Ala
Female
metabolism and adipogenesis
Research Paper
Zdroj: Adipocyte
ISSN: 2162-397X
2162-3945
Popis: The protective mechanisms of peroxisome proliferator-activated receptor gamma (PPARγ) Pro12Ala polymorphism in type 2 diabetes (T2D) are unclear. We obtained subcutaneous adipose tissue (AT) before and 3 h after oral glucose (OGTT) in carriers and non-carriers of the Ala allele (12 Pro/Pro, 15 Pro/Ala, and 13 Ala/Ala). Adipogenesis, adipocyte glucose uptake and lipolysis as well as PPARγ target gene expression were investigated and compared between the genotype groups. During fasting and post-OGTT, neither basal nor insulin-stimulated adipocyte glucose uptake differed between genotypes. Compared to fasting, a decreased hormone-sensitive lipase gene expression in Pro/Pro (p
Databáze: OpenAIRE