Osmotic nephropathy resulting from maltose-based intravenous immunoglobulin therapy

Autor:	George John, M.G. Kirubakaran, Bobby Chacko, N Balakrishnan, Chakko K. Jacob
Rok vydání:	2006
Předmět:	Nephrology Adult medicine.medical_specialty Lupus nephritis Pharmacology Critical Care and Intensive Care Medicine Immunoglobulin E Nephropathy Intravenous Immunoglobulin Therapy Osmotic nephrosis Internal medicine Medicine Humans Maltose biology business.industry Osmolar Concentration Immunoglobulins Intravenous General Medicine Acute Kidney Injury medicine.disease Lupus Nephritis Immunology biology.protein Female Antibody business Kidney disease
Zdroj:	Renal failure. 28(2)
ISSN:	0886-022X
Popis:	Intravenous immunoglobulin preparations are being used for an increasing number of indications. To minimize adverse reactions, sugar additives such as sucrose, maltose, and glycine are added to some preparations to serve as stabilizing agents. Intravenous immunoglobulin infusion induces acute renal failure (ARF) via a mechanism of osmotic nephrosis. Most reported cases are related to the use of sucrose-based intravenous immunoglobulin. Herein, we describe a patient with lupus nephritis treated with an immunoglobulin preparation containing maltose who developed ARF with histologic changes characterized by vacuolization and swelling of renal proximal tubular cells. Our case draws nephrologists' attention to the potential of maltose-based immunoglobulin in producing renal failure. Awareness and exercising caution in high-risk groups is elementary to the prevention of this condition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea580b71a13047844d4581a2555b0d4f https://pubmed.ncbi.nlm.nih.gov/16538981 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.