Enhancing chemotherapeutic drug inhibition on tumor growth by ultrasound: anin vivoexperiment
| Autor: | Ying-Zheng Zhao, Yan-Yan Xu, Wen-Feng Li, Zhuo Jin, Hui-Sheng Gao, Qin-Qin Tang, Wei Li, Zhicai Zhou, Lu Zhang, Cui-Tao Lu, Xiao-Kun Li, Ji-Lai Tian, Qi Xiang, Feng-Hou Gao, Chang-Zheng Sun |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Survival Hydrochloride medicine.medical_treatment Mice Nude Pharmaceutical Science HL-60 Cells Pharmacology Mice chemistry.chemical_compound Subcutaneous injection Drug Delivery Systems Leukemia Promyelocytic Acute In vivo Animals Humans Medicine Ultrasonics Tumor growth Phospholipids Epirubicin Mice Inbred BALB C Chemotherapy Antibiotics Antineoplastic Microbubbles business.industry Ultrasound chemistry Drug Screening Assays Antitumor business medicine.drug |
| Zdroj: | Journal of Drug Targeting. 19:154-160 |
| ISSN: | 1029-2330 1061-186X |
| DOI: | 10.3109/10611861003801834 |
| Popis: | An in vivo study on enhancing epirubicin hydrochloride (EPI) inhibition on tumor growth by ultrasound (US) was reported. Five-week-old male nude mice were used and HL-60 cells were s.c. (subcutaneous injection) inoculated in axilla of these mice. Six groups were designed and five consecutive treatments were applied to investigate the inhibition on tumor growth and body weight growth. US applied locally to the tumor resulted in a substantially increased drug uptake in tumor cells. The inhibition on tumor growth depended on the position of drug injection and phospholipid-based microbubble (PMB) application. Tumor growth rate under group 1 (PMB+US) was similar to that of blank control. The order of the inhibition on tumor volume growth was: group 4 (s.c. EPI+PMB+US) > group 5 intraperitoneal (i.p. EPI+PMB+US) > group 2 (i.p. EPI) > group 3 (s.c. EPI+US) > group 1 (PMB+US). Similar conclusion was obtained from experimental measurements of tumor weight change. The order of animal survival status for EPI administration groups was: group 4 > group 5 > group 2 > group 3. Chemotherapeutic drug inhibition on tumor growth could be enhanced by local US combined with PMB, which might provide a potential application for US-mediated chemotherapy. |
| Databáze: | OpenAIRE |
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