Ki-67 (30-9) scoring and differentiation of Luminal A- and Luminal B-like breast cancer subtypes
| Autor: | Amy E. Hanlon Newell, Greg Harlow, Patrizia Dell'Orto, Leila Russo, Espen Walker, Patrick Maisonneuve, Giuseppe Viale, Isaac Bai |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Epidemiology Estrogen receptor Breast Neoplasms Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Biomarkers Tumor Humans Medicine Neoplasm Staging Proportional Hazards Models biology business.industry Cell Differentiation Biomarker Luminal a medicine.disease Luminal B Luminal A Ki-67 Antigen 030104 developmental biology Case-Control Studies Differentiation 030220 oncology & carcinogenesis Ki-67 Monoclonal biology.protein Immunohistochemistry Biomarker (medicine) Female Neoplasm Grading business |
| Zdroj: | Breast Cancer Research and Treatment |
| ISSN: | 1573-7217 0167-6806 |
| Popis: | Introduction Ki-67 labeling index assessed by immunohistochemical assays has been shown useful in assessing the risk of recurrence for estrogen receptor (ER)-positive HER2-negative breast cancers (BC) and distinguishing Luminal A-like from Luminal B-like tumors. We aimed to assess the performance of the Ventana CONFIRM anti-Ki-67 (30-9) Rabbit Monoclonal Primary Antibody. Methods We constructed a case–cohort design based on a random sample (n = 679) of all patients operated on for a first primary, non-metastatic, ER-positive, HER2-negative BC at the European Institute of Oncology (IEO) Milan, Italy during 1998–2002 and all additional patients (n = 303) operated during the same period, who developed an event (metastasis in distant organs or death due to BC as primary event) and were not included in the previous subset. Multivariable Cox proportional hazards regression with inverse subcohort sampling probability weighting was used to evaluate the risk of event according to Ki-67 (30-9) and derived intrinsic molecular subtype, using previously defined cutoff values, i.e., respectively 14% and 20%. Results Ki-67 was |
| Databáze: | OpenAIRE |
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