Long-term observations of the clinical course after step down of corticosteroid inhalation therapy in adult chronic asthmatics: Correlation with serum levels of eosinophil cationic protein
| Autor: | Takeo Yagi, Kenji Baba, Hideo Wakayama, Sayaka Niwa, Ayako Sakakibara, Kenzo Takagi |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Prostaglandin Antagonists Exacerbation medicine.drug_class Gastroenterology Statistics Nonparametric Pranlukast Ribonucleases Internal medicine Benzoquinones medicine Humans Prospective Studies Glucocorticoids Aged Asthma Analysis of Variance Eosinophil cationic protein Inhalation Leukotriene receptor business.industry Beclomethasone Blood Proteins Eosinophil Granule Proteins Middle Aged Seratrodast Prognosis medicine.disease Chromones Heptanoic Acids Anesthesia Chronic Disease Respiratory Mechanics Leukotriene Antagonists Corticosteroid Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Respirology. 7:255-266 |
| ISSN: | 1440-1843 1323-7799 |
| Popis: | Background: Symptoms often deteriorate in well-controlled asthmatics after a step down in inhaled beclomethasone dipropionate (iBDP) therapy if the serum concentration of eosinophil cationic protein (sECP) is high. This deterioration is significantly abrogated by pranlukast, a leukotriene receptor antagonist, or by seratrodast, a thromboxane A2 receptor antagonist. However, these results were based on short-term (less than 6 months) observations. Methods: We studied 35 well-controlled adult asthmatics. We assigned the patients into different groups according to their sECP levels before the step down: (i) group A, sECP |
| Databáze: | OpenAIRE |
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