Whole-body autoradiography after systemic and topical administration of methyl acrylate in the guinea pig
| Autor: | E. Seutter, N. V. M. Rijntjes |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Administration Topical Skin Absorption Guinea Pigs Administration Oral Dermatology Guinea pig chemistry.chemical_compound Dermis Internal medicine Edema medicine Animals Tissue Distribution Respiratory system Methyl acrylate Skin General Medicine Metabolism Penetration (firestop) Endocrinology medicine.anatomical_structure Acrylates chemistry Biochemistry Carbon dioxide Autoradiography Methacrylates medicine.symptom Injections Intraperitoneal |
| Zdroj: | Archives of Dermatological Research. 270:273-284 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/bf00403931 |
| Popis: | Whole-body autoradiography was performed in the guinea pig with methyl (2,3-14C)-acrylate. Radioactive material quickly disappeared from the body after oral and, somewhat slower, after i. p. administration for the greater part. After administration in a closed cup on the skin a slow penetration in the dermis occurred preceded by the toxic effect, mainly a strong edema. In the first 16 h metabolism was primarily restricted to the skin, internal organs showed a slow rise in radioactivity. A large part of the labeled material was retained in the dermis. The detoxification was screened by estimating the urinary thioether content and respiratory carbon dioxide. This showed that in addition to oxidation to carbon dioxide the binding to SH-groups was the principal way of metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink