Anemia and Early Mortality in Patients with Decompensation of Chronic Heart Failure
| Autor: | Stefanos G. Foussas, Constantine N. Fakiolas, Kostas S. Karidis, Nikolaos G. Patsourakos, Andreas Melidonis, Michael N. Zairis, Athanasios A. Prekates, Anastassios Theodossis Georgilas, Pelagia C. Batika, Kyriakos S Argyrakis, Demetrios Z. Mytas |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Time Factors genetic structures Anemia Kaplan-Meier Estimate Severity of Illness Index Cohort Studies Cause of Death hemic and lymphatic diseases Internal medicine Severity of illness Confidence Intervals Humans Medicine Pharmacology (medical) Decompensation Hospital Mortality Survival analysis Aged Proportional Hazards Models Retrospective Studies Cause of death Heart Failure business.industry Proportional hazards model Length of Stay Middle Aged Prognosis medicine.disease Survival Analysis Hospitalization Heart failure Cardiology Female Hemoglobin Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiology. 119:125-130 |
| ISSN: | 1421-9751 0008-6312 |
| DOI: | 10.1159/000330494 |
| Popis: | Objectives: The possible independent effect of mild-to-moderate anemia (hemoglobin value not Methods: A total of 725 consecutive hospitalized patients were studied. All-cause mortalities during hospitalization and by day 31 were the prespecified study end points. Results: A total of 76 (10.5%) and 133 (18.3%) patients died during hospital stay and by day 31 of follow-up, respectively. Patients in the first hemoglobin tertile were at a significantly higher risk of death than those in the second (p = 0.003 and p < 0.001 for unadjusted in-hospital and 31-day mortality, respectively) or third terile (p < 0.001 and p < 0.001, for unadjusted in-hospital and 31-day mortality, respectively). However, after adjustment for concomitant baseline comorbidities and biochemical parameters, there was no significant difference in the risk of death among hemoglobin tertiles. Conclusions: Mild-to-moderate anemia seems not to contribute independently to short-term mortality in patients with decompensation of NYHA class III/IV chronic heart failure. An adverse concomitant baseline risk profile may have a key role in the induction of mild-to-moderate anemia and in the increased risk of death in these patients. |
| Databáze: | OpenAIRE |
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