The clinical value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) semi-quantitative parameters in monitoring neoadjuvant chemotherapy response of osteosarcoma
| Autor: | Yanni Zeng, Minyi Tan, Ting Song, Juan-ting Wang, Qiang Yuan, Bu-tian Zhang, Jian-feng Peng |
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| Rok vydání: | 2021 |
| Předmět: |
Contrast Media
030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance medicine Humans Radiology Nuclear Medicine and imaging Osteosarcoma Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging Neoadjuvant Therapy Dynamic contrast medicine.anatomical_structure Tumor morphology ROC Curve 030220 oncology & carcinogenesis Clinical value business Semi quantitative Chemotherapy response Blood vessel |
| Zdroj: | Acta radiologica (Stockholm, Sweden : 1987). 63(8) |
| ISSN: | 1600-0455 |
| Popis: | Background Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a non-invasive technique which could monitor tumor morphology, blood vessel dynamics, and micro-environmental changes. Purpose To evaluate the value of DCE-MRI semi-quantitative parameters in monitoring the neoadjuvant chemotherapy (NAC) response of osteosarcoma. Material and Methods Twenty-five patients pathologically confirmed as osteosarcoma received four cycles of NAC followed by surgery. All patients underwent conventional and dynamic MRI twice, before starting chemotherapy and before surgical treatment. With a reference standard of histological response (tumor necrosis rate), semi-quantitative parameters were compared between good response group (TNR ≥ 90%) and non-response group (TNR Results The changes were statistically significant on slope, maximum signal intensity (SImax), time to peak (TTP), signal enhanced extent (SEE), peak percent enhancement (PPE), washout rate (WOR), and enhancement rate (ER) in the good response group ( P max and SEE were different in the non-response group after NAC. The changes in Slope, SImax, TTP, SEE, WOR, and ER were markedly different ( P Conclusion Slope, TTP, and ER values could be used to evaluate and predict the response to NAC in osteosarcoma. |
| Databáze: | OpenAIRE |
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