Hypertension in High School Students: Genetic and Environmental Factors: The HYGEF Study
| Autor: | Laura Zagato, Giada Santini, Cristiano Magnaghi, Simona Delli Carpini, Chiara Lanzani, Marco Simonini, Gualtiero Ivanoe Colombo, Valeria Mezzolla, Giovanni Pertosa, Francesca Nistri, Simone Fontana, Salvatore Lenti, Filippo Cellai, Elisabetta Messaggio, Loreto Gesualdo, Roberto Bigazzi, Maria Teresa Rocchetti, Elena Brioni, Maria Pina Concas, Stefano Bianchi, Vito M. Campese, Paolo Manunta, Massimo Papale, Lorena Citterio |
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| Přispěvatelé: | Bigazzi, R., Zagato, L., Lanzani, C., Fontana, S., Messaggio, E., Delli Carpini, S., Citterio, L., Simonini, M., Brioni, E., Magnaghi, C., Colombo, G. I., Santini, G., Nistri, F., Cellai, F., Lenti, S., Bianchi, S., Pertosa, G. B., Rocchetti, M. T., Papale, M., Mezzolla, V., Gesualdo, L., Pina Concas, M., Campese, V., Manunta, P., Bigazzi, Roberto, Zagato, Laura, Lanzani, Chiara, Fontana, Simone, Messaggio, Elisabetta, Delli Carpini, Simona, Citterio, Lorena, Simonini, Marco, Brioni, Elena, Magnaghi, Cristiano, Ivanoe Colombo, Gualtiero, Santini, Giada, Nistri, Francesca, Cellai, Filippo, Lenti, Salvatore, Bianchi, Stefano, Battista Pertosa, Giovanni, Teresa Rocchetti, Maria, Papale, Massimo, Mezzolla, Valeria, Gesualdo, Loreto, Concas, MARIA PINA, Campese, Vito, Manunta, Paolo |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Candidate gene medicine.medical_specialty hypertension Adolescent Genotype Urinary system Single-nucleotide polymorphism Blood Pressure adolescents blood pressure genetics human sodiuria 030204 cardiovascular system & hematology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine medicine Humans Genetic Predisposition to Disease Endothelial dysfunction Klotho Alleles business.industry medicine.disease 030104 developmental biology Blood pressure ADD1 Endocrinology Pathophysiology of hypertension Hypertension Female Gene-Environment Interaction genetic business |
| Popis: | Hypertension and obesity in the young population are major risk factors for renal and cardiovascular events, which could arise in adulthood. A candidate-gene approach was applied in a cohort observational study, in which we collected data from 2638 high school adolescent students. Participants underwent anthropometric and blood pressure (BP) measurements, as well as saliva and urine sample collection for genomic DNA extraction and renal function evaluation, respectively. We tested whether candidate genes previously implicated in salt-sensitive hypertension in adults impact BP also among adolescents. Since inflammatory mechanisms may be involved in pathophysiology of hypertension and in endothelial dysfunction and atherosclerosis through reactive oxygen species, the baseline urinary excretion of inflammatory and oxidative stress markers in a subgroup of adolescents stratified according to ADD1 (alpha adducin) rs4961 genotypes was assessed. Regression analysis of BP values with genetic polymorphisms, highlighted an association with a missense variant of LSS (lanosterol synthase, rs2254524), a gene coding for an enzyme involved in endogenous ouabain synthesis. Higher diastolic and systolic BP were associated with LSS A allele ( P =0.011 and P =0.023, respectively). BP resulted associated with 5 more SNPs. The KL (klotho) rs9536314 missense variant was associated with 24 hour urinary Na + excretion ( P =0.0083). Urinary protein tests showed a greater excretion of IL1β (interleukin 1β) and interleukin 10 ( P ADD1 rs4961 T allele. In conclusion, 3 missense gene variants already implicated in adult hypertension impact BP or Na + excretion among adolescents, and, together with activated pro-inflammatory pathways, might predispose to early cardiovascular damage. |
| Databáze: | OpenAIRE |
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