Predictors of faster virological suppression in early treated infants with perinatal HIV from Europe and Thailand
| Autor: | Chan, Man K., Goodall, Ruth, Judd, Ali, Klein, Nigel, Chiappini, Elena, Klimkait, Thomas, Ngo-Giang-Huong, Nicole, Palma, Paolo, Rossi, Paolo, Thorne, Claire, Turkova, Anna, Zangari, Paola, Fraaij, Pieter L., Pajkrt, Dasja, Marques, Laura, Collins, Intira J., Gibb, Diana M., Gonzalez-Tome, Maria I., Navarro, Maria L., Ramos, Jose T., Noguera-Julian, Antoni, Warszawski, Josiane, Königs, Christoph, Spoulou, Vana, Prata, Filipa, Goetghebuer, Tessa, Galli, Luisa, Naver, Lars, Giaquinto, Carlo, Marczynska, Magdalena, Okhonskaia, Liubov, Malyuta, Ruslan, Volokha, Alla, Ene, Luminita, Rojo, Pablo, Babiker, Abdel G. A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Pediatrics Sustained Virologic Response Sida en l'embaràs HIV Infections Cohort Studies 0302 clinical medicine immune system diseases Interquartile range Antiretroviral Therapy Highly Active Immunology and Allergy 030212 general & internal medicine infants Hazard ratio Age Factors virus diseases Viral Load Clinical Science Thailand 3. Good health Europe Infectious Diseases Cohort ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Disease Progression Reverse Transcriptase Inhibitors Female Viral load virological suppression Cohort study Cart medicine.medical_specialty Immunology Drug Administration Schedule 03 medical and health sciences mental disorders medicine VIH (Virus) Humans early combination antiretroviral therapy Pregnancy Proportional hazards model business.industry HIV (Viruses) Infant Newborn Infant HIV Protease Inhibitors medicine.disease CD4 Lymphocyte Count AIDS (Disease) in pregnancy predictors 030104 developmental biology nervous system Drug withdrawal symptoms Multivariate Analysis Síndrome d'abstinència business perinatal HIV |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Aids r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname AIDS (London, England) |
| ISSN: | 0269-9370 |
| Popis: | Supplemental Digital Content is available in the text Objective: To identify predictors of faster time to virological suppression among infants starting combination antiretroviral therapy (cART) early in infancy. Design: Cohort study of infants from Europe and Thailand included in studies participating in the European Pregnancy and Paediatric HIV Cohort Collaboration. Methods: Infants with perinatal HIV starting cART aged less than 6 months with at least 1 viral load measurement within 15 months of cART initiation were included. Multivariable interval-censored flexible parametric proportional hazards models were used to assess predictors of faster virological suppression, with timing of suppression assumed to lie in the interval between last viral load at least 400 and first viral load less than 400 copies/ml. Results: Of 420 infants, 59% were female and 56% from Central/Western Europe, 26% United Kingdom/Ireland, 15% Eastern Europe and 3% Thailand; 46 and 54% started a boosted protease inhibitor-based or nonnucleoside reverse transcriptase inhibitor-based regimen, respectively. At cART initiation, the median age, CD4+% and viral load were 2.9 [interquartile range (IQR): 1.4–4.1] months, 34 (IQR: 24–45)% and 5.5 (IQR: 4.5–6.0) log10 copies/ml, respectively. Overall, an estimated 89% (95% confidence interval: 86–92%) achieved virological suppression within 12 months of cART start. In multivariable analysis, younger age [adjusted hazard ratio (aHR): 0.84 per month older; P |
| Databáze: | OpenAIRE |
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