Antigen-Specific Tissue-Resident Memory T Cells in the Respiratory System Were Generated following Intranasal Vaccination of Mice with BCG

Autor:	Jun Huang, Qiongli Wu, Shunqiao Wan, Changyou Wu, Shuangpeng Kang, Binyan Yang
Rok vydání:	2021
Předmět:	Chemokine Article Subject Immunology Mucous membrane of nose Stimulation Respiratory Mucosa Mice 03 medical and health sciences Immunogenicity Vaccine 0302 clinical medicine T-Lymphocyte Subsets Animals Humans Immunology and Allergy Medicine Respiratory system Tuberculosis Pulmonary Administration Intranasal CXCL16 030304 developmental biology 0303 health sciences biology business.industry Vaccination General Medicine RC581-607 Mycobacterium bovis Disease Models Animal Reinfection BCG Vaccine biology.protein Female Nasal administration Immunologic diseases. Allergy business Immunologic Memory CD8 Research Article 030215 immunology
Zdroj:	Journal of Immunology Research Journal of Immunology Research, Vol 2021 (2021)
ISSN:	2314-7156 2314-8861
DOI:	10.1155/2021/6660379
Popis:	Tissue-resident memory T cells (TRM) are different from effector memory T cells (TEM) and central memory T cells (TCM) and contribute to the protective immunity against local challenges. Currently, we found that CD4+ and CD8+ TRM cells in the nasal mucosa, trachea, lungs, and lavage fluids were heterogeneous on the expression of CD69 and CD103 as well as the production of cytokines including IFN-γ, IL-2, and TNF-α. After intranasal vaccination of mice with BCG, respiratory tissues expressed higher levels of the chemokine CXCL16 and TRM cells expressed CXCR6 to CXCL16. In addition, antigen-specific CD4+ and CD8+ TRM cells expressed cytokines following the stimulation with BCG and persisted in the nasal mucosa, trachea, and lungs for more than a hundred days. At the same time, mice were infected intranasally with live BCG and the results showed that vaccinated mice cleared up live BCG faster than nonvaccinated mice in the respiratory system. Taken together, our data demonstrated that intranasal vaccination of mice with BCG could induce antigen-specific CD4+ and CD8+ TRM cells in the respiratory system and have the ability to provide protection against pulmonary reinfection.
Databáze:	OpenAIRE
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