Blockade of α2-adrenoceptors protects the vagal baroreflex system from transient global cerebral ischemia in dogs
| Autor: | Hitoshi Kato, Satoru Tamaoki, Junichi Kurihara |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Ischemia Baroreflex Dioxanes chemistry.chemical_compound Dogs Phentolamine Idazoxan Receptors Adrenergic alpha-1 Ifenprodil Animals Medicine cardiovascular diseases Adrenergic alpha-Antagonists Pharmacology biology business.industry Fissipedia Vagus Nerve biology.organism_classification medicine.disease Yohimbine Blockade nervous system chemistry Ischemic Attack Transient Anesthesia Adrenergic alpha-1 Receptor Antagonists Female business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 240:73-76 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(93)90547-u |
| Popis: | Ifenprodil, phentolamine, yohimbine or idazoxan, 1 mg/kg i.v., administered 5 min prior to 5-min global cerebral ischemia, completely prevented the post-ischemic dysfunction of the vagal baroreflex in anesthetized dogs. Idazoxan, 0.1 mg/kg i.v., was cerebroprotective against mild ischemia, but ineffective against severe ischemia. The post-ischemic administration of idazoxan, 1 mg/kg i.v., failed to restore the damaged vagal baroreflex. These results suggest that blockade of α 2 -adrenoceptors during ischemia and the early reperfusion period may protect the vagal component of baroreflex from cerebral ischemia. |
| Databáze: | OpenAIRE |
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