Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database

Autor: Anthea Ng, Kamlesh Khunti, Azeem Majeed, Ioanna Tzoulaki, Robert Hughes, Mark P. Little, Vasa Curcin, Mariam Molokhia, Martin R. Wilkins, Christopher Millett, Paul Elliott
Rok vydání: 2009
Předmět:
Heart Failure/*chemically induced
Male
Myocardial Infarction
Administration
Oral
Type 2 diabetes
030204 cardiovascular system & hematology
Fractures
Bone
0302 clinical medicine
Sulfonylurea Compounds/*administration & dosage/adverse effects
Risk Factors
Myocardial infarction
Metformin/administration & dosage/adverse effects
General Environmental Science
Diabetes
General Engineering
Absolute risk reduction
General Medicine
Hypoglycemic Agents/*administration & dosage
Middle Aged
Metformin
3. Good health
Myocardial Infarction/*chemically induced/mortality
Female
Diabetic Angiopathies/*chemically induced/mortality
Rosiglitazone
Cohort study
medicine.drug
medicine.medical_specialty
Fractures
Bone/chemically induced
030209 endocrinology & metabolism
Ischaemic Heart Disease
Diabetes Mellitus
Type 2/*drug therapy/mortality
03 medical and health sciences
Drugs: Cardiovascular System
Internal medicine
medicine
Humans
Hypoglycemic Agents
Risk factor
Aged
Retrospective Studies
Heart Failure
Pioglitazone
Thiazolidinediones/administration & dosage/adverse effects
business.industry
Research
Retrospective cohort study
medicine.disease
Surgery
Epidemiologic Studies
Sulfonylurea Compounds
Diabetes Mellitus
Type 2
Metabolic Disorders
General Earth and Planetary Sciences
Thiazolidinediones
business
Diabetic Angiopathies
Zdroj: The BMJ
BMJ
ISSN: 1468-5833
0959-8138
DOI: 10.1136/bmj.b4731
Popis: OBJECTIVE: To investigate the risk of incident myocardial infarction, congestive heart failure, and all cause mortality associated with prescription of oral antidiabetes drugs. DESIGN: Retrospective cohort study. SETTING: UK general practice research database, 1990-2005. PARTICIPANTS: 91,521 people with diabetes. MAIN OUTCOME MEASURES: Incident myocardial infarction, congestive heart failure, and all cause mortality. Person time intervals for drug treatment were categorised by drug class, excluding non-drug intervals and intervals for insulin. RESULTS: 3588 incident cases of myocardial infarction, 6900 of congestive heart failure, and 18,548 deaths occurred. Compared with metformin, monotherapy with first or second generation sulphonylureas was associated with a significant 24% to 61% excess risk for all cause mortality (P
Databáze: OpenAIRE
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