Pneumococcal Extracellular Serine Proteases: Molecular Analysis and Impact on Colonization and Disease
| Autor: | Gerhard Burchhardt, Lukas Schulig, Murtadha Q. Ali, Sven Hammerschmidt, Thomas P. Kohler |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Proteases Immunology Review Biology medicine.disease_cause Microbiology virulence factor Virulence factor Pneumococcal Infections Serine Cellular and Infection Microbiology respiratory infection Streptococcus pneumoniae Extracellular medicine Humans Trypsin structure pneumococcal serine protease Immunogenicity pathogenesis Serine Endopeptidases Subtilisin Respiratory infection colonization QR1-502 Otitis Media Infectious Diseases Interaction with host |
| Zdroj: | Frontiers in Cellular and Infection Microbiology Frontiers in Cellular and Infection Microbiology, Vol 11 (2021) |
| ISSN: | 2235-2988 |
| Popis: | The pathobiontStreptococcus pneumoniaecauses life-threatening diseases, including pneumonia, sepsis, meningitis, or non-invasive infections such as otitis media. Serine proteases are enzymes that have been emerged during evolution as one of the most abundant and functionally diverse group of proteins in eukaryotic and prokaryotic organisms.S. pneumoniaeexpresses up to four extracellular serine proteases belonging to the category of trypsin-like or subtilisin-like family proteins: HtrA, SFP, PrtA, and CbpG. These serine proteases have recently received increasing attention because of their immunogenicity and pivotal role in the interaction with host proteins. This review is summarizing and focusing on the molecular and functional analysis of pneumococcal serine proteases, thereby discussing their contribution to pathogenesis. |
| Databáze: | OpenAIRE |
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