Effects of Omega-3 Fatty Acid Supplementation on Diabetic Nephropathy Progression in Patients with Diabetes and Hypertriglyceridemia

Autor: Yujung Yun, Yong Ho Lee, Byung Wan Lee, Bong Soo Cha, Eugene Han, Eun Seok Kang, Beom Seok Kim, Gyuri Kim, Hye Jin Wang
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Physiology
lcsh:Medicine
Blood Pressure
030204 cardiovascular system & hematology
Urine
urologic and male genital diseases
Gastroenterology
Biochemistry
Vascular Medicine
Diabetic nephropathy
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Chronic Kidney Disease
Medicine and Health Sciences
Medicine
Diabetic Nephropathies
lcsh:Science
Hypertriglyceridemia
Multidisciplinary
Drugs
Middle Aged
Lipids
Body Fluids
Cholesterol
Nephrology
Disease Progression
Female
medicine.symptom
Anatomy
Research Article
Glomerular Filtration Rate
medicine.medical_specialty
Endocrine Disorders
Renal function
030209 endocrinology & metabolism
03 medical and health sciences
Internal medicine
Diabetes mellitus
Fatty Acids
Omega-3
Diabetes Mellitus
Albuminuria
Humans
Aged
Retrospective Studies
Pharmacology
Creatinine
Renal Physiology
Triglyceride
business.industry
lcsh:R
Statins
Biology and Life Sciences
Renal System
medicine.disease
Logistic Models
chemistry
Metabolic Disorders
lcsh:Q
business
Kidney disease
Zdroj: PLoS ONE, Vol 11, Iss 5, p e0154683 (2016)
PLoS ONE
ISSN: 1932-6203
Popis: Beneficial effects of omega-3 fatty acid (O3FA) supplementation in a wide range of disease condition have been well studied. However, there is limited information regarding the effects of O3FAs on chronic kidney disease (CKD), especially in diabetic nephropathy (DN) with hypertriglyceridemia. We investigate whether O3FA supplementation could help maintain renal function in patients with diabetes and hypertriglyceridemia. Total 344 type 2 diabetic patients with a history of O3FA supplementation for managing hypertriglyceridemia were included. Reduction in urine albumin to creatinine ratio (ACR) and glomerular filtrate rate (GFR) were examined. Subgroup analyses were stratified according to the daily O3FA doses. Serum total cholesterol, triglyceride, and urine ACR significantly reduced after O3FA supplementation. Overall, 172 (50.0%) patients did not experience renal function loss, and 125 (36.3%) patients had a GFR with a positive slope. The patients treated with O3FAs at 4g/day showed greater maintenance in renal function than those treated with lower dosages (p < 0.001). This dose dependent effect remains significant after adjustment for multiple variables. O3FA supplementation in diabetic patients with hypertriglyceridemia shows benefits of reducing albuminuria and maintaining renal function. The effects are dependent on the dose of daily O3FA supplementation.
Databáze: OpenAIRE
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