Prevalence, Characteristics, and Outcome of Cow's Milk Protein Allergy in Chinese Infants: A Population‐Based Survey
| Autor: | Xiaoxiu Li, Lanlan Geng, Xiaoling Long, Min Yang, Jie-Ling Wu, Sitang Gong, Yong Zhang, Yongmei Zeng, Yuan Wang, Hai-Jin Ke, Huabo Cai, Yulian Xiao, Huiwen Li, Zhuojie Chen, Huan Chen, Kelvin Li, Meizhen Tan, Hongli Wang, Linhui Rong, Peiyu Chen, Jing Xie, Ding-You Li, Simao Fu, Hong Wang, Ying Liu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
China Allergy Pediatrics medicine.medical_specialty 030309 nutrition & dietetics Population Breastfeeding Medicine (miscellaneous) Atopy 03 medical and health sciences 0302 clinical medicine Risk Factors Food allergy Prevalence Animals Humans Medicine Family Prospective Studies Family history education Anaphylaxis 0303 health sciences education.field_of_study Nutrition and Dietetics Cesarean Section business.industry Oral food challenge Infant Allergens Immunoglobulin E Milk Proteins medicine.disease Health Surveys Bottle Feeding Telephone interview Cattle Female 030211 gastroenterology & hepatology Milk Hypersensitivity business |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 43:803-808 |
| ISSN: | 1941-2444 0148-6071 |
| Popis: | Background Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence of CMPA in Chinese infants. The aim of this population-based study is to determine the prevalence, clinical characteristics, and outcome of CMPA in Chinese infants. Methods We carried out a prospective survey in 7 participating hospitals throughout southern China. We included infants ≤12 months of age during the survey. For those suspected of CMPA, oral food challenge with cow's milk protein (CMP) was performed. A follow-up telephone interview was conducted at 12 months after the diagnosis to assess the clinical outcome of CMPA. Results A total of 9910 questionnaire surveys were distributed and 7364 (74.3%) were returned. The eligible survey number of surveys was 6768 (91.9%). A total of 182 infants was confirmed with CMPA, including 13 with anaphylactic reactions, 28 with clinical symptoms and serum immunoglobulin E (sIgE) >3.5 IU/mL, and 141 with positive CMP challenge test. The prevalence of CMPA was 2.69%. Infants with confirmed CMPA had significantly stronger family history of either 1 or both parents with food allergy, higher Cesarean section rate, and lower rate of breastfeeding, compared with those without CMPA. At 12-month telephone follow-up of 176 CMPA infants, 136 infants (77.3%) had become tolerant to CMP. Conclusions The prevalence of CMPA was 2.69%. CMPA infants had a strong family history of food allergy and atopy. Both Cesarean delivery and formula feeding were risk factors for CMPA. At 12-month follow-up, the majority of CMPA infants had become tolerant to CMP. |
| Databáze: | OpenAIRE |
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