Development and validation of a stability-indicating UPLC method for rosuvastatin and its related impurities in pharmaceutical dosage forms
| Autor: | Bobba Venkateswara Reddy, Jung Hag Park, Poonam Kumar, Syed Wasimul Haque, Avvaru Praveen Kumar, Gosula Venkat Ram Reddy, Haum Dutt Gautam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Química Nova, Volume: 34, Issue: 2, Pages: 250-255, Published: 2011 Química Nova v.34 n.2 2011 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ Química Nova, Vol 34, Iss 2, Pp 250-255 (2011) |
| Popis: | The present work describes a novel stability-indicating reversed-phase ultra performance liquid chromatography method for the separation and quantification of rosuvastatin (RSV) and its related impurities in the pharmaceutical dosage forms under forced degradation conditions. An unknown degradation impurity detected in the acid degradation was identified by using quadrupole time-of-flight mass spectrometry. The chromatographic separation was carried out on C-18 column (100 x 2.1 mm, 1.7 μm) using isocratic elution with methanol and 0.1% trifluoroacetic acid (50:50). The total run time was 12 min within which RSV as well as all related impurities and degradation products were separated. The developed method was validated for RSV and related impurities in pharmaceutical dosage forms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|