Preparation and evaluation of lactic acid acylated exenatide and its long-acting preparation

Autor:	Kaoxiang Sun, Liuxiang Chu, Aiping Wang, Fenghua Fu, Rongcai Liang, Linlin Wang, Xiuju Yan
Rok vydání:	2019
Předmět:	Blood Glucose Male Agonist medicine.drug_class Acylation Drug Compounding Pharmaceutical Science Mice Inbred Strains 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Glucagon-Like Peptide-1 Receptor Diabetes Mellitus Experimental Microsphere Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Diabetes mellitus Animals Hypoglycemic Agents Medicine Lactic Acid Receptor business.industry General Medicine 021001 nanoscience & nanotechnology medicine.disease Microspheres Lactic acid Drug Liberation Long acting chemistry Delayed-Action Preparations Exenatide 0210 nano-technology business medicine.drug
Zdroj:	Pharmaceutical Development and Technology. 24:1229-1235
ISSN:	1097-9867 1083-7450
DOI:	10.1080/10837450.2019.1651857
Popis:	Exenatide (EX), a glucagon-like peptide-1 receptor agonist, is used to treat diabetes mellitus. However, its short half-life necessitates frequent administration and fluctuations in its plasma concentration may cause adverse effects. Previously, we developed glycolic acid acylated EX, which showed a good glucose-lowering effect. However, the release of lactic acid (LA) acylated exenatide (LA-EX) as an acylated adduct in EX microspheres has not been studied. Here, we investigated the biological properties of LA-EX. Additionally, LA-EX-loaded microspheres were formulated by an emulsion-solvent evaporation method and their
Databáze:	OpenAIRE
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