Effects of High-Potency Cannabis on Psychomotor Performance in Frequent Cannabis Users
| Autor: | L. Cinnamon Bidwell, William DeJong, Angela D. Bryan, Ashley Brooks-Russell, Jessica Streufert, Hollis C. Karoly, Nicholas P. Lovrich, Mary Brown, Michael A. Milburn |
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| Rok vydání: | 2022 |
| Předmět: |
Cannabinoid Receptor Agonists
Pharmacology Psychomotor learning medicine.medical_specialty biology business.industry Canna Marijuana Smoking Cannabis use biology.organism_classification Complementary and alternative medicine Hallucinogens Humans Medicine Potency Pharmacology (medical) Cannabis Psychomotor Disorders business Psychiatry Neurocognitive Psychomotor Performance Original Research |
| Zdroj: | Cannabis Cannabinoid Res |
| ISSN: | 2378-8763 2578-5125 |
| Popis: | Background: Recently increased access to cannabis products in the United States has been associated with increased rates of driving after cannabis use. Although numerous studies indicate that cannabis impairs psychomotor and neurocognitive functions that can affect driving ability, the determination of cannabis-impaired driving risk is complicated by the extent to which frequent cannabis users develop tolerance to THC's subjective, cognitive, and psychomotor effects, and by the fact that there is no validated behavioral or biological marker of recent cannabis use or cannabis-related impairment. This study examined the psychomotor impairment-related effects experienced by frequent cannabis users in Colorado after naturalistic consumption of smoked cannabis, both immediately and 1 h postuse. Results were then validated in a smaller replication sample from Washington state. Methods: In the primary Colorado study, participants (n=70) used the DRUID(®) mobile app, a brief measure of psychomotor and cognitive domains that are sensitive to the effects of cannabis. First, participants used DRUID to establish a sober baseline impairment score. During a second appointment, they used DRUID at three time points: preuse, immediately after acutely using cannabis, and 1 h postuse. In the Washington replication sample, participants (n=39) used DRUID before acute cannabis consumption and then every half hour for 2.5 h. Results: In both studies, peak DRUID impairment effects were seen immediately after cannabis use, with recovery of performance at 1 h postuse. Specifically, significant quadratic effects of time emerged for both studies (Colorado study: (β=−0.935, SE=0.204, p |
| Databáze: | OpenAIRE |
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