Age and Prostate-Specific Antigen Level Prior to Diagnosis Predict Risk of Death from Prostate Cancer
| Autor: | Thomas B. Neville, F. Roy MacKintosh, Michael W. Kattan, Christopher H. Morrell, Louise C. Walter, Cayce Nawaf, Preston C. Sprenkle, R. Jeffrey Karnes, Lori Rawson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Urologic Diseases
Oncology Aging Cancer Research medicine.medical_specialty death risk Oncology and Carcinogenesis 030232 urology & nephrology 03 medical and health sciences Prostate cancer 0302 clinical medicine Clinical Research Prostate Internal medicine Medicine prostate-specific antigen older men Veterans Affairs Cancer Original Research business.industry Prevention medicine.disease prostate cancer 3. Good health Prostate-specific antigen medicine.anatomical_structure Increased risk 030220 oncology & carcinogenesis Life expectancy life expectancy Risk of death business |
| Zdroj: | Frontiers in Oncology |
| ISSN: | 2234-943X |
| Popis: | A single early prostate-specific antigen (PSA) level has been correlated with a higher likelihood of prostate cancer diagnosis and death in younger men. PSA testing in older men has been considered of limited utility. We evaluated prostate cancer death in relation to age and PSA level immediately prior to prostate cancer diagnosis. Using the Veterans Affairs database, we identified 230,081 men aged 50-89 years diagnosed with prostate cancer and at least one prior PSA test between 1999 and 2009. Prostate cancer-specific death over time was calculated for patients stratified by age group (e.g., 50-59 years, through 80-89 years) and PSA range at diagnosis (10 ranges) using Kaplan-Meier methods. Risk of 10-year prostate cancer mortality across age and PSA was compared using log-rank tests with a Bonferroni adjustment for multiple testing. 10.5% of men diagnosed with prostate cancer died of cancer during the 10-year study period (mean follow-up = 3.7 years). Higher PSA values prior to diagnosis predict a higher risk of death in all age groups (p |
| Databáze: | OpenAIRE |
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