Intestinal barrier dysfunction is associated with elevated right atrial pressure in patients with advanced decompensated heart failure

Autor:	Takeshi Kitai, Ina Nemet, Timothy Engelman, Rommel Morales, Thanat Chaikijurajai, Kathryn Morales, Stanley L. Hazen, W.H. Wilson Tang
Rok vydání:	2022
Předmět:	Cohort Studies Heart Failure Hospitalization Atrial Pressure Risk Factors Humans Cardiology and Cardiovascular Medicine
Zdroj:	American Heart Journal. 245:78-80
ISSN:	0002-8703
Popis:	We prospectively performed serial differential sugar absorption test in 29 consecutively consented patients with advanced decompensated heart failure admitted to the heart failure intensive care unit for hemodynamically-guided therapy. We observed that intestinal barrier function was significantly impaired in our study cohort, and increased intestinal permeability was associated with elevated right atrial pressure and poorer prognosis yet without any association with systemic levels of the gut microbial metabolite, trimethylamine N-oxide (TMAO) or intestinal fatty acid binding protein that were thought to be indicative of intestinal abnormalities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4374ca79c41e064e59f35bedc294ed https://doi.org/10.1016/j.ahj.2021.11.014 Zobrazit plný text záznamu Full Text from ScienceDirect