Follicular development induced by recombinant luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in anovulatory women with LH and FSH deficiency: evidence of a threshold effect
| Autor: | Fanny O’Brien, Karen Currie, G. Hemsey, Louis St. L. O’Dea |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Adolescent Hormone Replacement Therapy media_common.quotation_subject Anovulation Andrology Follicle-stimulating hormone Ovarian Follicle Pregnancy Internal medicine Follicular phase medicine Humans Ovarian follicle Ovulation Amenorrhea media_common Estradiol business.industry General Medicine Luteinizing Hormone medicine.disease Recombinant Proteins Endocrinology medicine.anatomical_structure Female Follicle Stimulating Hormone Human business Luteinizing hormone Hypogonadotrophic hypogonadism Hormone |
| Zdroj: | Current medical research and opinion. 24(10) |
| ISSN: | 1473-4877 |
| Popis: | To assess the requirement for luteinizing hormone (LH) in women deficient in LH and follicle-stimulating hormone (FSH).A prospective, randomized, parallel-group, multicentre study was carried out in tertiary care and academic medical centres. Women with anovulatory amenorrhoeaor = 1 year, serum oestradiol (E(2))60 pg/mL (220 pmol/L) and low normal serum gonadotrophins were randomized in cycle A to a fixed daily dose of recombinant human (r-h) FSH (150 IU) and r-hLH 0, 25, 75 or 225 IU. Cycles B and C were not randomized.Follicular development, ovulation and luteinization.In cycle A, follicular development was achieved by 63.6% (7/11), 100% (9/9), 72.7% (8/11) and 66.7% (6/9) of patients who received r-hFSH and r-hLH 0, 25, 75 or 225 IU/day, respectively (p = not significant). Among patients with basal serum LH of1.2 IU/L, a dose-response relationship of r-hLH to follicular development was observed (p = 0.039). Fourteen of 34 patients (41.2%) wishing to conceive became pregnant. Among patients with hypogonadotrophic hypogonadism (HH) treated with r-hFSH alone, a transition from LH dependence to independence was observed between basal LH values ofor = 1.2 IU/L andor = 1.6 IU/L. The r-hLH was well tolerated and no serious adverse events occurred during treatment. The most common treatment-related events were related to the reproductive system and the gastrointestinal tract.Recombinant human LH provides a safe treatment option for women with HH. This small study also provided evidence suggestive of an LH threshold: follicular development was suboptimal when less than 75 IU/day r-hLH was administered. |
| Databáze: | OpenAIRE |
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