PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study
| Autor: | Zsolt Sarszegi, Attila Gyenesei, Péter Ferdinandy, Ádám Németh, Anikó Görbe, Attila Cziráki, Andrea Tamas, András Makkos, Róbert Herczeg, Zsuzsanna Helyes, Beata Polgar, Éva Sághy, Dora Reglodi, Dóra Szabó |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Swine medicine.medical_treatment Myocardial Infarction 030204 cardiovascular system & hematology lcsh:Chemistry 0302 clinical medicine Risk Factors Myocardial infarction Non-ST Elevated Myocardial Infarction prognostic factor Receptor lcsh:QH301-705.5 pituitary adenylate cyclase activating polypeptide Spectroscopy Cardioprotection biology General Medicine Middle Aged Troponin Computer Science Applications Treatment Outcome medicine.anatomical_structure cardioprotection Cardiology Pituitary Adenylate Cyclase-Activating Polypeptide Female ELISA hormones hormone substitutes and hormone antagonists endocrine system medicine.medical_specialty Heart Ventricles acute myocardial infarction closed-chest myocardial infarction model Neuropeptide Article Catalysis STEMI Inorganic Chemistry 03 medical and health sciences Percutaneous Coronary Intervention Internal medicine medicine Animals Humans cardiovascular diseases Physical and Theoretical Chemistry Molecular Biology Aged Glycated Hemoglobin business.industry Organic Chemistry Percutaneous coronary intervention Arrhythmias Cardiac medicine.disease lcsh:Biology (General) lcsh:QD1-999 Ventricle Conventional PCI biology.protein ST Elevation Myocardial Infarction business 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 2883, p 2883 (2021) International Journal of Molecular Sciences Volume 22 Issue 6 |
| ISSN: | 1422-0067 |
| Popis: | Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI. |
| Databáze: | OpenAIRE |
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