Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS
| Autor: | Emily O'Kearney, Sandra L Neate, George A Jelinek, Keryn L Taylor, Tracey J Weiland, Alysha M De Livera, Steve Simpson, Chelsea R Brown, William Bevens |
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| Rok vydání: | 2018 |
| Předmět: |
Gerontology
Adult Male Multiple Sclerosis Adolescent International Cooperation Overweight Cohort Studies 03 medical and health sciences Disability Evaluation Young Adult 0302 clinical medicine Age Distribution Quality of life Surveys and Questionnaires medicine Humans 030212 general & internal medicine Prospective cohort study Depression (differential diagnoses) Fatigue Aged Demography Aged 80 and over Psychiatric Status Rating Scales Marital Status business.industry Depression General Medicine Middle Aged medicine.disease Comorbidity Antidepressive Agents Patient Health Questionnaire Neurology Quality of Life Marital status Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Multiple sclerosis and related disorders. 30 |
| ISSN: | 2211-0356 |
| Popis: | Background Depression is highly prevalent among people with MS, and determinants thereof would be useful. Objectives We examined the relationship of demographic and clinical factors with positive depression-screen and change in depression over 2.5 years in people with MS. Methods Positive depression-screen assessed by Patient Health Questionnaire (PHQ)-2 and PHQ-9. Associations of demographic and clinical factors with depression-screen and change thereof assessed using multivariable regression models, adjusted for age, sex, disability, fatigue, antidepressant use, and baseline PHQ-2, as appropriate. Results Overweight/obese BMI, comorbidity number, fatigue, and disability were associated with positive depression-screen, while married/partnered state, being employed, higher perceived socioeconomic status, and greater education were inversely associated with depression-screen. After adjustment, only marital status, socioeconomic status, antidepressant medication use, and fatigue were associated with risk of newly positive depression-screen. MS type, relapse number and immunomodulatory medication use were not associated with depression-screen after controlling for disability and fatigue. Conclusion In a large prospective cohort study of depression in people with MS, we substantiated several potential determinants of a positive depression-screen and depression trajectory, particularly fatigue. Given that fatigue is the most common and most significant clinical symptom for people with MS, efforts to reduce fatigue may have follow-on benefits for reducing depression. |
| Databáze: | OpenAIRE |
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