Acute ischaemic stroke associated with SARS-CoV-2 infection in North America
| Autor: | Adam A Dmytriw, Mahmoud Dibas, Kevin Phan, Aslan Efendizade, Johanna Ospel, Clemens Schirmer, Fabio Settecase, Manraj K S Heran, Anna Luisa Kühn, Ajit S Puri, Bijoy K Menon, Sanjeev Sivakumar, Askan Mowla, Daniel Vela-Duarte, Italo Linfante, Guilherme C Dabus, Robert W Regenhardt, Salvatore D'Amato, Joseph A Rosenthal, Alicia Zha, Nafee Talukder, Sunil A Sheth, Ameer E Hassan, Daniel L Cooke, Lester Y Leung, Adel M Malek, Barbara Voetsch, Siddharth Sehgal, Ajay K Wakhloo, Mayank Goyal, Hannah Wu, Jake Cohen, Sherief Ghozy, David Turkel-Parella, Zerwa Farooq, Justin E Vranic, James D Rabinov, Christopher J Stapleton, Ramandeep Minhas, Vinodkumar Velayudhan, Zeshan Ahmed Chaudhry, Andrew Xavier, Maria Bres Bullrich, Sachin Pandey, Luciano A Sposato, Stephen A Johnson, Gaurav Gupta, Priyank Khandelwal, Latisha Ali, David S Liebeskind, Mudassir Farooqui, Santiago Ortega-Gutierrez, Fadi Nahab, Dinesh V Jillella, Karen Chen, Mohammad Ali Aziz-Sultan, Mohamad Abdalkader, Artem Kaliaev, Thanh N Nguyen, Diogo C Haussen, Raul G Nogueira, Israr Ul Haq, Osama O Zaidat, Emma Sanborn, Thabele M Leslie-Mazwi, Aman B Patel, James E Siegler, Ambooj Tiwari |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Neurology, Neurosurgery, and Psychiatry Neuroscience Institute Publications |
| Popis: | BackgroundTo analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome.MethodsMulticentre retrospective cohort study of COVID-19 patients with AIS who presented to 30 stroke centres in the USA and Canada between 14 March and 30 August 2020. The primary endpoint was poor functional outcome, defined as a modified Rankin Scale (mRS) of 5 or 6 at discharge. Secondary endpoints include favourable outcome (mRS ≤2) and mortality at discharge, ordinal mRS (shift analysis), symptomatic intracranial haemorrhage (sICH) and occurrence of in-hospital complications.ResultsA total of 216 COVID-19 patients with AIS were included. 68.1% (147/216) were older than 60 years, while 31.9% (69/216) were younger. Median [IQR] National Institutes of Health Stroke Scale (NIHSS) at presentation was 12.5 (15.8), and 44.2% (87/197) presented with large vessel occlusion (LVO). Approximately 51.3% (98/191) of the patients had poor outcomes with an observed mortality rate of 39.1% (81/207). Age >60 years (aOR: 5.11, 95% CI 2.08 to 12.56, pConclusionThere is relationship between COVID-19-associated AIS and severe disability or death. We identified several factors which predict worse outcomes, and these outcomes were more frequent compared to global averages. We found that elevated neutrophil-to-lymphocyte ratio, rather than D-Dimer, predicted both morbidity and mortality. |
| Databáze: | OpenAIRE |
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