Reverting estrogen-receptor-negative phenotype in HER-2-overexpressing advanced breast cancer patients exposed to trastuzumab plus chemotherapy
| Autor: | A. Rocca, Elisabetta Munzone, Giuseppe Renne, Aron Goldhirsch, Giuseppe Curigliano, Giuseppina Bonizzi, Franco Nolè |
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| Jazyk: | angličtina |
| Předmět: |
Paclitaxel
Receptor ErbB-2 Estrogen receptor Antineoplastic Agents Breast Neoplasms Antibodies Monoclonal Humanized Vinblastine Breast cancer Surgical oncology Trastuzumab Progesterone receptor Antineoplastic Combined Chemotherapy Protocols Medicine Endocrine system Humans skin and connective tissue diseases Infusions Intravenous Medicine(all) business.industry Cancer Antibodies Monoclonal Vinorelbine medicine.disease Primary tumor Immunohistochemistry Phenotype Treatment Outcome Receptors Estrogen Immunology Cancer research Disease Progression Female business Receptors Progesterone medicine.drug Research Article |
| Zdroj: | Breast Cancer Research |
| ISSN: | 1465-542X |
| DOI: | 10.1186/bcr1366 |
| Popis: | Introduction The amounts of estrogen receptor (ER) and progesterone receptor (PgR) in a primary tumor are predictive of the response to endocrine therapies of breast cancer. Several patients with ER-positive primary tumors relapse after adjuvant endocrine therapy with no ER expression in the recurrent tissue; much fewer with a recurrent disease after an ER-negative primary tumor may become endocrine responsive. These sequences of events indicate that a phenotype based on ER expression may not be a permanent feature of breast cancer. Methods Ten patients with advanced breast cancer whose tumors overexpressed HER-2, but not ER or PgR, were treated with weekly trastuzumab at standard doses with or without chemotherapy. Results Three out of 10 patients showed overexpression of ERs first appearing after 9, 12 and 37 weeks, respectively, from the initiation of trastuzumab. Two of these patients were subsequently treated with endocrine therapy alone: one of them received letrozole for 3 years without evidence of progression. Conclusion Therapeutic targets enabling the appearance of an endocrine responsive disease may increase treatment options for patients with breast cancer. Furthermore, these clinical data suggest that an ER-negative phenotype is a multi-step process with a reversible repression modality, and that some ER-negative tumors may either revert to an ER-positive phenotype, allowing an endocrine treatment to be effective. |
| Databáze: | OpenAIRE |
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