Management of chronic prostatitis/chronic pelvic pain syndrome
| Autor: | Nickel Jc, Doiron Rc |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Funnel plot business.industry medicine.drug_class Urology Antibiotics 030232 urology & nephrology Review Publication bias Placebo medicine.disease Confidence interval Surgery 03 medical and health sciences FAVORABLE RESPONSE 0302 clinical medicine Oncology Chronic prostatitis/chronic pelvic pain syndrome Internal medicine Medicine 030212 general & internal medicine business Beneficial effects |
| Zdroj: | Canadian Urological Association Journal. 12:S161-3 |
| ISSN: | 1920-1214 1911-6470 |
| Popis: | �1.7 (95% confidence interval [CI], �2.8 to �0.6), �1.1 (95% CI, �1.8 to �0.3), �1.4 (95% CI, �2.3 to �0.5), and �1.0 (95% CI, �1.8 to �0.2), respectively. Patients receiving -blockers or anti-inflammatory medications had a higher chance of favorable response compared with placebo, with pooled RRs of 1.6 (95% CI, 1.1-2.3) and 1.8 (95% CI, 1.2-2.6), respectively. Contour-enhanced funnel plots suggested the presence of publication bias for smaller studies of -blocker therapies. The network meta-analysis suggested benefits of antibiotics in decreasing total symptom scores (�9.8; 95% CI, �15.1 to �4.6), pain scores (�4.4; 95% CI, �7.0 to �1.9), voiding scores (�2.8; 95% CI, �4.1 to �1.6), and quality-of-life scores (�1.9; 95% CI, �3.6 to �0.2) compared with placebo. Combining-blockers and antibiotics yielded the greatest benefits compared with placebo, with corresponding decreases of �13.8 (95% CI, �17.5 to �10.2) for total symptom scores, �5.7 (95% CI, �7.8 to �3.6) for pain scores, �3.7 (95% CI, �5.2 to �2.1) for voiding, and �2.8 (95% CI, �4.7 to �0.9) for quality-of-life scores. Conclusions -Blockers,antibiotics,andcombinationsofthesetherapiesappeartoachieve the greatest improvement in clinical symptom scores compared with placebo. Antiinflammatory therapies have a lesser but measurable benefit on selected outcomes. However, beneficial effects of -blockers may be overestimated because of publication bias. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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