Assessment of the structural brain network reveals altered connectivity in children with unilateral cerebral palsy due to periventricular white matter lesions

Autor: Andrea Guzzetta, Stephen E. Rose, Roslyn N. Boyd, Simona Fiori, Kerstin Pannek
Rok vydání: 2014
Předmět:
Male
Congenital hemiplegia
Pathology
FMAM
fit model to all measurements
lcsh:RC346-429
FA
fractional anisotropy
Child
AHA
assisting hand assessment
Brain network
Brain
DROP-R
detection and replacement of outliers prior to resampling
GMFCS
gross motor function classification system
Magnetic Resonance Imaging
White Matter
Unilateral cerebral palsy
medicine.anatomical_structure
Neurology
Child
Preschool
Periventricular white matter lesions
Connectome
lcsh:R858-859.7
Female
Psychology
Tractography
medicine.medical_specialty
Adolescent
Leukomalacia
Periventricular
Cognitive Neuroscience
lcsh:Computer applications to medicine. Medical informatics
Article
Diffusion MRI
Cerebral palsy
White matter
CTD
children with typical development
medicine
Humans
Radiology
Nuclear Medicine and imaging
CDGM
cortical and deep grey matter
CP
cerebral palsy
NBS
network based statistic
lcsh:Neurology. Diseases of the nervous system
MACS
manual ability classification system
HARDI
high angular resolution diffusion imaging
Cerebral Palsy
HOMOR
higher order model outlier rejection
PWM
periventricular white matter
medicine.disease
Sensory function
Neurology (clinical)
Nerve Net
Neuroscience
Zdroj: NeuroImage: Clinical, Vol 5, Iss C, Pp 84-92 (2014)
NeuroImage : Clinical
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2014.05.018
Popis: Background Cerebral palsy (CP) is a term to describe the spectrum of disorders of impaired motor and sensory function caused by a brain lesion occurring early during development. Diffusion MRI and tractography have been shown to be useful in the study of white matter (WM) microstructure in tracts likely to be impacted by the static brain lesion. Aim The purpose of this study was to identify WM pathways with altered connectivity in children with unilateral CP caused by periventricular white matter lesions using a whole-brain connectivity approach. Methods Data of 50 children with unilateral CP caused by periventricular white matter lesions (5–17 years; manual ability classification system [MACS] I = 25/II = 25) and 17 children with typical development (CTD; 7–16 years) were analysed. Structural and High Angular Resolution Diffusion weighted Images (HARDI; 64 directions, b = 3000 s/mm2) were acquired at 3 T. Connectomes were calculated using whole-brain probabilistic tractography in combination with structural parcellation of the cortex and subcortical structures. Connections with altered fractional anisotropy (FA) in children with unilateral CP compared to CTD were identified using network-based statistics (NBS). The relationship between FA and performance of the impaired hand in bimanual tasks (Assisting Hand Assessment—AHA) was assessed in connections that showed significant differences in FA compared to CTD. Results FA was reduced in children with unilateral CP compared to CTD. Seven pathways, including the corticospinal, thalamocortical, and fronto-parietal association pathways were identified simultaneously in children with left and right unilateral CP. There was a positive relationship between performance of the impaired hand in bimanual tasks and FA within the cortico-spinal and thalamo-cortical pathways (r2 = 0.16–0.44; p
Highlights • Alterations in FA in children with CP were assessed using the connectome approach. • FA is reduced in corticospinal, thalamocortical, and association tracts in CP. • Higher FA is associated with better performance in bimanual tasks.
Databáze: OpenAIRE
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