Neutralization Profiles of Newly Transmitted Human Immunodeficiency Virus Type 1 by Monoclonal Antibodies 2G12, 2F5, and 4E10
| Autor: | Hermann Katinger, Gabriela Stiegler, Justin Galovich, Sandhya Vasan, Arlene Hurley, Brigitta Vcelar, Christine Hogan, Saurabh Mehandru, Terri Wrin, Christos J. Petropoulos, Martin Markowitz |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.drug_class Sexual Behavior Immunology HIV Infections HIV Antibodies Monoclonal antibody Recombinant virus Microbiology Virus Neutralization Immune system Neutralization Tests Virology medicine Humans Recombination Genetic biology Antibodies Monoclonal biology.organism_classification Insect Science Lentivirus biology.protein HIV-1 Pathogenesis and Immunity Female Viral disease Antibody |
| Popis: | As the AIDS epidemic continues unabated, the development of a human immunodeficiency virus (HIV) vaccine is critical. Ideally, an effective vaccine should elicit cell-mediated and neutralizing humoral immune responses. We have determined the in vitro susceptibility profile of sexually transmitted viruses from 91 patients with acute and early HIV-1 infection to three monoclonal antibodies, 2G12, 2F5, and 4E10. Using a recombinant virus assay to measure neutralization, we found all transmitted viruses were neutralized by 4E10, 80% were neutralized by 2F5, and only 37% were neutralized by 2G12. We propose that the induction of 4E10-like antibodies should be a priority in designing immunogens to prevent HIV-1 infection. |
| Databáze: | OpenAIRE |
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