Altered spontaneous brain activity pattern in patients with ophthalmectomy: an resting-state fMRI study
| Autor: | Biao Li, Yi Shao, You-Lan Min, Qi Lin, Bing Zhang, Yong-Qiang Shu, Qing Yuan, Rongqiang Liu, Pei-Wen Zhu, Lei Ye |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cerebellum Brain activity and meditation degree centrality Correlation 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Clinical Research Internal medicine medicine ophthalmectomy resting state Pathological medicine.diagnostic_test Resting state fMRI Receiver operating characteristic business.industry Lobe Ophthalmology medicine.anatomical_structure lcsh:RE1-994 030221 ophthalmology & optometry Cardiology spontaneous brain activity Functional magnetic resonance imaging business |
| Zdroj: | International Journal of Ophthalmology, Vol 13, Iss 2, Pp 263-270 (2020) |
| ISSN: | 2227-4898 2222-3959 |
| Popis: | Aim To use the voxel-wise degree centrality (DC) method to explore the underlying functional network brain-activity in patients with ophthalmectomy. Methods A total of 32 ophthalmic surgery patients (10 women and 22 men), and 32 healthy subjects (10 women and 22 men) highly matched in gender, age, and the same operation method. Everyone experienced a resting-state functional magnetic resonance imaging scan. The spontaneous brain activity could be assessed by DC. Correlation analysis was used to explore the relationships between the average DC signal values and behavior performance in different regions. Receiver operating characteristic (ROC) curve analysis was utilized to differentiate between ophthalmectomy patients and healthy controls (HCs). Results Compared with HCs, ophthalmectomy patients had greatly reduced DC values in left lingual gyrus, bilateral lingual lobe, left cingulate gyrus, and increased DC values of left cerebellum posterior lobe, left middle frontal gyrus1, right supramarginal gyrus, left middle frontal gyrus2, right middle frontal gyrus. However, we did not find that there was a correlation between the average DC values from various brain regions and clinical manifestations. Conclusion Dysfunction may be caused by ophthalmectomy in lots of cerebral areas, which may show the potential pathological mechanism of ophthalmectomy and it is beneficial to clinical diagnosis. |
| Databáze: | OpenAIRE |
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