In vitro infection of smooth muscle cells by Chlamydia pneumoniae
| Autor: | Parakat Vijayagopal, David H. Martin, Julio E. Figueroa, Erin Knoebel |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Immunology
Cell Count Chlamydia trachomatis Biology medicine.disease_cause Microbiology Cell Line Antigen medicine Animals Humans Chlamydiaceae Chlamydia Muscle Smooth Chlamydia Infections Chlamydophila pneumoniae medicine.disease biology.organism_classification Virology Immunity Innate In vitro Endothelial stem cell Cholesterol Infectious Diseases Cell culture Cattle Parasitology Rabbits Research Article |
| Zdroj: | Infection and Immunity. 65:503-506 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | Recent observations have shown that both Chlamydia pneumoniae antigens and DNA may be found within atherosclerotic lesions. In this study, we evaluated the ability of C. pneumoniae to infect cells that make up atherosclerotic lesions, including endothelial cells, smooth muscle cells, and cholesterol-loaded smooth muscle cells. The organism readily infected rabbit, bovine, and human aortic smooth muscle cells. Cholesterol-loaded smooth muscle cells were even more susceptible to C. pneumoniae infection. Chlamydia trachomatis inefficiently infected smooth muscle cells, demonstrating that this is not a characteristic of all members of the genus Chlamydia. C. pneumoniae infected bovine endothelial cells poorly. This study demonstrates that C. pneumoniae readily infects one of the important types of cells found within atherosclerotic lesions, i.e., smooth muscle cells with and without cholesterol loading. |
| Databáze: | OpenAIRE |
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