Tobacco smoking and binge alcohol use are associated with incident venous thromboembolism in an HIV cohort

Autor:	Brandon Luu, Stephanie Ruderman, Robin Nance, Joseph A. C. Delaney, Jimmy Ma, Andrew Hahn, Susan R. Heckbert, Matthew J. Budoff, Kristina Crothers, William C. Mathews, Katerina Christopolous, Peter W. Hunt, Joseph Eron, Richard Moore, Jeanne Keruly, William B. Lober, Greer A. Burkholder, Amanda Willig, Geetanjali Chander, Mary E. McCaul, Karen Cropsey, Conall O'Cleirigh, Inga Peter, Matthew Feinstein, Judith I. Tsui, Sara Lindstroem, Michael Saag, Mari M. Kitahata, Heidi M. Crane, Lydia N. Drumright, Bridget M. Whitney
Rok vydání:	2022
Předmět:	and promotion of well-being venous thromboembolism Clinical Sciences substance use HIV Infections Cardiovascular smoking Binge Drinking Substance Misuse Alcohol Use and Health Clinical Research Risk Factors Virology Tobacco Tobacco Smoking Humans Pharmacology (medical) cardiovascular diseases Prospective Studies Cancer Proportional Hazards Models Tobacco Smoke and Health Ethanol Prevention Health Policy HIV Venous Thromboembolism Prevention of disease and conditions Stroke Alcoholism Good Health and Well Being Infectious Diseases Respiratory HIV/AIDS 3.1 Primary prevention interventions to modify behaviours or promote wellbeing
Zdroj:	HIV medicine, vol 23, iss 10
ISSN:	1468-1293
Popis:	BackgroundPeople with HIV (PWH) are at increased risk of cardiovascular comorbidities and substance use is a potential predisposing factor. We evaluated associations of tobacco smoking and alcohol use with venous thromboembolism (VTE) in PWH.MethodsWe assessed incident, centrally adjudicated VTE among 12957 PWH within the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort between January 2009 and December 2018. Using separate Cox proportional hazards models, we evaluated associations of time-updated alcohol and cigarette use with VTE, adjusting for demographic and clinical characteristics. Smoking was evaluated as pack-years and never, former, or current use with current cigarettes per day. Alcohol use was parameterized using categorical and continuous alcohol use score, frequency of use, and binge frequency.ResultsDuring a median of 3.6years of follow-up, 213 PWH developed a VTE. One-third of PWH reported binge drinking and 40% reported currently smoking. In adjusted analyses, risk of VTE was increased among both current (HR: 1.44, 95% CI: 1.02-2.03) and former (HR: 1.44, 95% CI: 0.99-2.07) smokers compared to PWH who never smoked. Additionally, total pack-years among ever-smokers (HR: 1.10 per 5 pack-years; 95% CI: 1.03-1.18) was associated with incident VTE in a dose-dependent manner. Frequency of binge drinking was associated with incident VTE (HR: 1.30 per 7days/month, 95% CI: 1.11-1.52); however, alcohol use frequency was not. Severity of alcohol use was not significantly associated with VTE.ConclusionsCurrent smoking and pack-year smoking history were dose-dependently associated with incident VTE among PWH in CNICS. Binge drinking was also associated with VTE. Interventions for smoking and binge drinking may decrease VTE risk among PWH.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea388422bd1192e0900894b5dc4c7bcd https://pubmed.ncbi.nlm.nih.gov/35343038 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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