The absorbing filter Oxiris in severe coronavirus disease 2019 patients: A case series
Autor: | Hongtao Zhang, Fengmin Shao, Qiying Fang, Guizhen Zhu, Lei Yan, Yang Lu |
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Rok vydání: | 2020 |
Předmět: |
Male
Thoughts & Progress ARDS Organ Dysfunction Scores medicine.medical_treatment Medicine (miscellaneous) Blood Pressure 02 engineering and technology 030204 cardiovascular system & hematology Gastroenterology Procalcitonin law.invention 0302 clinical medicine Heart Rate law APACHE Aged 80 and over Respiratory Distress Syndrome APACHE II General Medicine Middle Aged Intensive care unit C-Reactive Protein cytokine storm Female Cytokine Release Syndrome Adult medicine.medical_specialty Mean arterial pressure Continuous Renal Replacement Therapy 0206 medical engineering Biomedical Engineering Renal function Bioengineering Biomaterials 03 medical and health sciences COVID‐19 hemodynamic Internal medicine Heart rate Oxiris medicine Humans Renal replacement therapy Aged Retrospective Studies business.industry Interleukins COVID-19 Membranes Artificial medicine.disease 020601 biomedical engineering Oxygen business |
Zdroj: | Artificial Organs |
ISSN: | 1525-1594 0160-564X |
DOI: | 10.1111/aor.13786 |
Popis: | Hypercytokines cause acute respiratory distress syndrome (ARDS) in coronavirus disease 2019 (COVID-19) patients, which is the main reason for intensive care unit treatment and the leading cause of death in COVID-19 patients. Cytokine storm is a critical factor in the development of ARDS. This study evaluated the efficacy and safety of Oxiris filter in the treatment of COVID-19 patients. Five patients with COVID-19 who received continuous renal replacement therapy (CRRT) in Henan provincial people's hospital between January 23, 2019 and March 28, 2020, were enrolled in this study. Heart rate (HR), mean arterial pressure (MAP), oxygenation index (PaO2 /FiO2 ), renal function, C-reactive protein (CRP), cytokines, procalcitonin (PCT), acute physiology and chronic health evaluation II (APACHE II), sequential organ failure score (SOFA), and prognosis were compared after CRRT. Five COVID-19 patients, three males and two females, aged 70.2 ± 19.6 years, were enrolled. After treatment, HR (101.4 ± 14.08 vs. 83.8 ± 6.22 bpm/min), CRP (183 ± 25.21 vs. 93.78 ± 70.81 mg/L), IL-6 (3234.49 (713.51, 16038.36) vs. 181.29 (82.24, 521.39) pg/mL), IL-8 (154.86 (63.97, 1476.1) vs. 67.19 (27.84, 85.57) pg/mL), and IL-10 (17.43 (9.14, 41.22) vs. 4.97 (2.39, 8.70) pg/mL), APACHE II (29 ± 4.92 vs. 18.4 ± 2.07), and SOFA (17.2 ± 1.92 vs. 11.2 ± 3.4) significantly decreased (P < .05), while MAP (75.8 ± 4.92 vs. 85.8 ± 6.18 mm Hg), and PaO2 /FiO2 (101.2 ± 7.49 vs. 132.6 ± 26.15 mm Hg) significantly increased (P < .05). Among the five patients, negative conversion of nucleic acid test was found in three cases, while two cases died. No adverse events occurred during the treatment. Our study observed a reduced level of overexpressed cytokines, stabilization of hemodynamic status, and staged improvement of organ function during the treatment with Oxiris filter. |
Databáze: | OpenAIRE |
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