The absorbing filter Oxiris in severe coronavirus disease 2019 patients: A case series

Autor: Hongtao Zhang, Fengmin Shao, Qiying Fang, Guizhen Zhu, Lei Yan, Yang Lu
Rok vydání: 2020
Předmět:
Male
Thoughts & Progress
ARDS
Organ Dysfunction Scores
medicine.medical_treatment
Medicine (miscellaneous)
Blood Pressure
02 engineering and technology
030204 cardiovascular system & hematology
Gastroenterology
Procalcitonin
law.invention
0302 clinical medicine
Heart Rate
law
APACHE
Aged
80 and over

Respiratory Distress Syndrome
APACHE II
General Medicine
Middle Aged
Intensive care unit
C-Reactive Protein
cytokine storm
Female
Cytokine Release Syndrome
Adult
medicine.medical_specialty
Mean arterial pressure
Continuous Renal Replacement Therapy
0206 medical engineering
Biomedical Engineering
Renal function
Bioengineering
Biomaterials
03 medical and health sciences
COVID‐19
hemodynamic
Internal medicine
Heart rate
Oxiris
medicine
Humans
Renal replacement therapy
Aged
Retrospective Studies
business.industry
Interleukins
COVID-19
Membranes
Artificial

medicine.disease
020601 biomedical engineering
Oxygen
business
Zdroj: Artificial Organs
ISSN: 1525-1594
0160-564X
DOI: 10.1111/aor.13786
Popis: Hypercytokines cause acute respiratory distress syndrome (ARDS) in coronavirus disease 2019 (COVID-19) patients, which is the main reason for intensive care unit treatment and the leading cause of death in COVID-19 patients. Cytokine storm is a critical factor in the development of ARDS. This study evaluated the efficacy and safety of Oxiris filter in the treatment of COVID-19 patients. Five patients with COVID-19 who received continuous renal replacement therapy (CRRT) in Henan provincial people's hospital between January 23, 2019 and March 28, 2020, were enrolled in this study. Heart rate (HR), mean arterial pressure (MAP), oxygenation index (PaO2 /FiO2 ), renal function, C-reactive protein (CRP), cytokines, procalcitonin (PCT), acute physiology and chronic health evaluation II (APACHE II), sequential organ failure score (SOFA), and prognosis were compared after CRRT. Five COVID-19 patients, three males and two females, aged 70.2 ± 19.6 years, were enrolled. After treatment, HR (101.4 ± 14.08 vs. 83.8 ± 6.22 bpm/min), CRP (183 ± 25.21 vs. 93.78 ± 70.81 mg/L), IL-6 (3234.49 (713.51, 16038.36) vs. 181.29 (82.24, 521.39) pg/mL), IL-8 (154.86 (63.97, 1476.1) vs. 67.19 (27.84, 85.57) pg/mL), and IL-10 (17.43 (9.14, 41.22) vs. 4.97 (2.39, 8.70) pg/mL), APACHE II (29 ± 4.92 vs. 18.4 ± 2.07), and SOFA (17.2 ± 1.92 vs. 11.2 ± 3.4) significantly decreased (P < .05), while MAP (75.8 ± 4.92 vs. 85.8 ± 6.18 mm Hg), and PaO2 /FiO2 (101.2 ± 7.49 vs. 132.6 ± 26.15 mm Hg) significantly increased (P < .05). Among the five patients, negative conversion of nucleic acid test was found in three cases, while two cases died. No adverse events occurred during the treatment. Our study observed a reduced level of overexpressed cytokines, stabilization of hemodynamic status, and staged improvement of organ function during the treatment with Oxiris filter.
Databáze: OpenAIRE