Factors associated with resistance to complications in long-standing type 1 diabetes in China
| Autor: | Yanai Wang, Xiaoling Cai, Wei Liu, Linong Ji, Yu Zhu, Mingxia Zhang, Xueyao Han, Juan Li, Siqian Gong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
type 1 diabetes Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Lower risk lcsh:Diseases of the endocrine glands. Clinical endocrinology Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Endocrinology longevity Diabetes mellitus Internal medicine Internal Medicine Medicine 030212 general & internal medicine Socioeconomic status Type 1 diabetes lcsh:RC648-665 business.industry Research diabetic nephropathy Diabetic retinopathy medicine.disease diabetic retinopathy Blood pressure Rural area business |
| Zdroj: | Endocrine Connections, Vol 9, Iss 2, Pp 187-193 (2020) Endocrine Connections |
| ISSN: | 2049-3614 |
| Popis: | Objective Type 1 diabetes (T1DM) is associated with a higher risk of premature death, but there are factors in certain patients with T1DM that protect them from complications and premature death. These factors had not been identified in non-Caucasian populations, so we aimed to identify factors that protect against the development of diabetic nephropathy (DN) and diabetic retinopathy (DR) in long-standing T1DM in China. Methods Ninety-five T1DM patients with >30 years’ duration of diabetes were enrolled in this nationwide study. Differences between groups of patients with and without complications were compared, and multivariable regression analysis was used to evaluate the relationships between candidate protective factors and the development of DN or DR. Results Thirty of the participants did not have DN and the same amount did not have DR. 6/52 of participants without DN were from a rural area, whereas 11/28 of participants with DN had been born in a rural area (P = 0.005). Systolic blood pressure (SBP) was higher in participants with DN (135 ± 26 mmHg vs 121 ± 13 mmHg; P = 0.002). In participants without DR, 27/30 were married or cohabitating, and only 3/30 were single, never married, or widowed, but for those with proliferative DR (PDR), 13/26 had been married (P = 0.003). A rural or urban origin and SBP were associated with DN in the multivariable analysis. Conclusion we have shown that higher socioeconomic status, indicated by birth in an urban area, and being married or cohabitating, are accompanied by better blood pressure control and a lower risk of microvascular complications in Chinese patients with long-standing T1DM. These findings illustrate the importance of improving care for patients with T1DM in China. |
| Databáze: | OpenAIRE |
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