Lack of relationship between endothelial nitric oxide synthase gene 4b/a and T-786C polymorphisms with preeclampsia in southeast of Iran
| Autor: | Minoo Yaghmaei, Mojgan Mokhtari, Mehrangiz Noora, Saeedeh Salimi, Anoosh Naghavi |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Genotype Nitric Oxide Synthase Type III Iran Preeclampsia Young Adult Gene Frequency Pre-Eclampsia Polymorphism (computer science) Pregnancy Internal medicine medicine Humans Endothelium Gene reproductive and urinary physiology Alleles Fetus Polymorphism Genetic Endothelial nitric oxide synthase biology business.industry Afghanistan Obstetrics and Gynecology General Medicine medicine.disease female genital diseases and pregnancy complications Nitric oxide synthase Endocrinology Cross-Sectional Studies embryonic structures biology.protein Severe morbidity Regression Analysis Female business |
| Zdroj: | Archives of gynecology and obstetrics. 285(2) |
| ISSN: | 1432-0711 |
| Popis: | Preeclampsia is an important disorder of pregnancy that carries a severe morbidity and mortality risk for both mother and fetus. A large number of studies have shown that abnormalities in nitric oxide synthesis may contribute to the development of preeclampsia.We examined the relationship between the endothelial nitric oxide synthase (eNOS) gene 4b/a and T-786C polymorphisms with preeclampsia (PE) in 123 preeclamptic pregnant women and 142 healthy pregnant women in the southeast of Iran.Our findings indicate that the 4b/a and T-786C polymorphisms of eNOS gene do not have any association with preeclampsia, but we found that the risk of preeclampsia was twofold in Afghan women in contrast to Persian and Balooch women. In a backward stepwise multiple regression analysis, the Afghan race and the history of preeclampsia were the risk factors for preeclampsia.We conclude that the presence of 4b/a and T-786C polymorphisms were not risk factors for preeclampsia. |
| Databáze: | OpenAIRE |
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