Gamma Knife Radiosurgery of the Glomus Jugulare Tumour - Early Multicentre Experience
| Autor: | R. Martinez, W. Pellet, Vilibald Vladyka, D. M. C. Forster, Roman Liscak, Gerhard Pendl, J. A. Burzaco, B. Wowra, Sandro Eustacchio, Andras A. Kemeny, Jean Régis |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Radiosurgery Central nervous system disease Postoperative Complications medicine Humans Aged Neuroradiology Aged 80 and over Neurologic Examination medicine.diagnostic_test business.industry Glomus Jugulare Tumor Interventional radiology Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Treatment Outcome Angiography Female Surgery Neurology (clinical) Neurosurgery Tomography X-Ray Computed business Nuclear medicine Follow-Up Studies |
| Zdroj: | Acta Neurochirurgica. 141:1141-1146 |
| ISSN: | 0942-0940 0001-6268 |
| Popis: | Leksell Gamma Knife was used to treat 66 patients with glomus jugulare tumour at 6 European sites between 1992-1998. The age of the patients ranged between 18-80 years (median 54 years). Gamma Knife radiosurgery was a primary treatment in 30 patients (45. 5%). Open surgery preceded radiosurgery in 24 patients (36.4%), embolisation in 14 patients (21.2%) and fractionated radiotherapy in 5 patients (7.6%). The volume of the tumour ranged 0.5-27 cm(3) (median 5,7 cm(3)). The minimal dose to the tumour margin ranged between 10-30 Gy (median 16.5 Gy). After radiosurgery 52 patients were followed, the follow up period was 3-70 months (median 24 months). Neurological deficit improved in 15 patients (29%) and deteriorated in 3 patients (5,8%), one transient and two persistant. Neuroradiological follow up using MRI or CT was performed in 47 patients 4-70 months (median 24 months) after radiosurgery. Tumour size decreased in 19 patients (40%) while in the remaining 28 patients (60%) no change in the tumour volume was observed. None of the tumours increased in volume during the observation period. Control angiography was performed in 6 patients. Pathological vascularisation completely disappeared in one patient, reduced in two and there was no change in the remaining three. Radiosurgery proves to be a safe treatment for glomus jugulare tumour with no mortality and no acute morbidity. Because of its naturally slow growth rate, up to 10 years of follow up will be necessary to establish a cure rate after radiosurgery for these lesions. |
| Databáze: | OpenAIRE |
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