The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke
| Autor: | Merdin Š. Markišić, Dragan M. Pavlović, Aleksandra M. Pavlović |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Homocysteine Article Subject Barthel index lcsh:Medicine 030204 cardiovascular system & hematology Gastroenterology General Biochemistry Genetics and Molecular Biology Brain Ischemia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Modified Rankin Scale Internal medicine Ischaemic stroke medicine Vitamin D and neurology Humans Vitamin B12 Vitamin D Stroke Aged Aged 80 and over General Immunology and Microbiology business.industry lcsh:R Recovery of Function General Medicine Middle Aged medicine.disease Surgery Vitamin B 12 chemistry Female business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Biomed Research International BioMed Research International, Vol 2017 (2017) BioMed Research International |
| Popis: | We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r=0.304,p<0.05), B12 level (r=-0.410,p<0.01), and vitamin D levels (r=-0.465,p<0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up. |
| Databáze: | OpenAIRE |
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