Risk and protective factors of co-morbid depression in patients with type 2 diabetes mellitus: a meta analysis
| Autor: | Patamu Mohemaiti, Aidibai Simayi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Protective factor 030209 endocrinology & metabolism Subgroup analysis Comorbidity Diabetes Complications 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine medicine Humans Risk factor Exercise Depression (differential diagnoses) Marital Status Depression business.industry Smoking Type 2 Diabetes Mellitus Protective Factors Diabetes Mellitus Type 2 Socioeconomic Factors 030220 oncology & carcinogenesis Meta-analysis Marital status Female Observational study business |
| Zdroj: | Endocrine Journal. 66:793-805 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.ej18-0579 |
| Popis: | The aim from this paper is to identify the main influencing factors of co-morbid depression among T2DM (Type 2 Diabetes Mellitus) patients and to provide reliable evidence for relative researches. A systematic review and meta-analysis of risk factors for co-morbid depression in T2DM was performed on all retrieved studies through an observational research of network database. Data were analyzed by Review Manager 5.3 from the extracted results, the heterogeneity index of the studies was determined using Chi-squared I2 tests and on the basis of heterogeneity, a fixed or random effect model was used to estimates the pooled effect of each influencing factor. Fourteen observational studies containing total of 82,239,298 cases that have been identified. Diabetic complications (OR = 2.91; 95%CI, 1.76-4.82, p < 0.0001), insulin use (OR = 1.71; 95%CI, 1.18-2.48, p = 0.005), education status (OR = 1.91; 95%CI, 1.30-2.81, p = 0.001) were confirmed as risk factors, while regular exercising (OR = 0.51; 95%CI, 0.27-0.96, p = 0.04), gender (OR = 0.56; 95%CI, 0.47-0.65, p < 0.0001), marital status (OR = 0.53; 95%CI, 0.34-0.83, p = 0.005), current social status (OR = 0.64; 95%CI, 0.47-0.88, p = 0.006) were confirmed as protective factors of co-morbid depression in the patients with T2DM. Subgroup analysis claimed age (≥60 years) was a risk factor and smoking was protective factor for co-morbid depression in the patients with T2DM. Being female, have diabetic complications, insulin use, education level less than secondary are risk factors. However, doing regular exercise, being married and on work are protective factors of co-morbid depression in patients with T2DM. As to the other influencing factors should be further studied. |
| Databáze: | OpenAIRE |
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