Estradiol impairs the Th17 immune response against Candida albicans
| Autor: | César Nombela, Laura Aragoneses-Fenoll, Gema Romera, Christelle Bourgeois, Karl Kuchler, Rosalía Diez-Orejas, Angel L. Corbí, Miguel Relloso, José Luis Rodríguez-Fernández, Sandra Lasarte, M. Ángeles Muñoz-Fernández |
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| Rok vydání: | 2011 |
| Předmět: |
Ovariectomy
Immunology Antigen presentation Estrous Cycle Biology Microbiology Mice Immune system In vivo Cell Movement Candida albicans Hormone replacement therapy (male-to-female) medicine Immunology and Allergy Animals Pathogen Antigen Presentation Mice Inbred BALB C Estradiol Candidiasis Cell Biology Dendritic Cells medicine.disease biology.organism_classification Th17 Cells Female Systemic candidiasis Disease Susceptibility hormones hormone substitutes and hormone antagonists Ex vivo |
| Zdroj: | Journal of leukocyte biology. 91(1) |
| ISSN: | 1938-3673 |
| Popis: | Candida albicans is a commensal opportunistic pathogen that is also a member of gastrointestinal and reproductive tract microbiota. Exogenous factors, such as oral contraceptives, hormone replacement therapy, and estradiol, may affect susceptibility to Candida infection, although the mechanisms involved in this process have not been elucidated. We used a systemic candidiasis model to investigate how estradiol confers susceptibility to infection. We report that estradiol increases mouse susceptibility to systemic candidiasis, as in vivo and ex vivo estradiol-treated DCs were less efficient at up-regulating antigen-presenting machinery, pathogen killing, migration, IL-23 production, and triggering of the Th17 immune response. Based on these results, we propose that estradiol impairs DC function, thus explaining the increased susceptibility to infection during estrus. |
| Databáze: | OpenAIRE |
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