Various plus unique: Viral protein U as a plurifunctional protein for HIV-1 replication
| Autor: | Yusuke Nakano, Andrew Soper, Yoshio Koyanagi, Miyu Moriwaki, Guillermo Juarez-Fernandez, Eri Yamada, Kei Sato, Hirofumi Aso |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gene Expression Regulation Viral Viral protein animal diseases viruses Human Immunodeficiency Virus Proteins Genome Viral Biology medicine.disease_cause Virus Replication General Biochemistry Genetics and Molecular Biology Virus 03 medical and health sciences Immunology/Microbiology/Virology Viral structural protein medicine Viral Regulatory and Accessory Proteins Gene virus diseases Simian immunodeficiency virus biochemical phenomena metabolism and nutrition Virology 030104 developmental biology Viral replication Tetherin HIV-1 Function (biology) |
| Zdroj: | Experimental biology and medicine (Maywood, N.J.). 242(8) |
| ISSN: | 1535-3699 |
| Popis: | Human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome, encodes four accessory genes, one of which is viral protein U (Vpu). Recently, the study of Vpu has been of great interest. For instance, various cellular proteins are degraded (e.g. CD4) and down-modulated (e.g. tetherin) by Vpu. Vpu also antagonizes the function of tetherin and inhibits NF-κB. Moreover, Vpu is a viroporin forming ion channels and may represent a promising target for anti-HIV-1 drugs. In this review, we summarize the domains/residues that are responsible for Vpu’s functions, describe the current understanding of the role of Vpu in HIV-1-infected cells, and review the effect of Vpu on HIV-1 in replication and pathogenesis. Future investigations that simultaneously assess a combination of Vpu functions are required to clearly delineate the most important functions for viral replication. Impact statement Viral protein U (Vpu) is a unique protein encoded by human immunodeficiency virus type 1 (HIV-1) and related lentiviruses, playing multiple roles in viral replication and pathogenesis. In this review, we briefly summarize the most up-to-date knowledge of HIV-1 Vpu. |
| Databáze: | OpenAIRE |
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