Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks
| Autor: | Si Tu, Jian-Rong He, Xiu Qiu, Songying Shen, Lifang Zhang, Wei Bao, Wan-Qing Xiao, Kar Keung Cheng, Arnaud Fontanet, Anna L Funk, Jinhua Lu, Li Yang, Jia Yu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
China medicine.medical_specialty Microcephaly Population Reproductive medicine Gestational Age Logistic regression lcsh:Gynecology and obstetrics Risk Assessment Infant Newborn Diseases 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors 030225 pediatrics Prevalence Humans Medicine 030212 general & internal medicine Pregnancy Complications Infectious Risk factor education lcsh:RG1-991 education.field_of_study Fetal Growth Retardation Zika Virus Infection business.industry Obstetrics Infant Newborn Obstetrics and Gynecology Gestational age Preterm birth Zika Virus Small for gestational age Hepatitis B medicine.disease Parity Attributable risk Premature Birth Female business Research Article |
| Zdroj: | BMC Pregnancy and Childbirth BMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1471-2393 |
| DOI: | 10.1186/s12884-021-03705-9 |
| Popis: | Background Prevalence of neonatal microcephaly in populations without Zika-epidemics is sparse. The study aimed to report baseline prevalence of congenital microcephaly and its relationship with prenatal factors in an area at risk of Zika outbreak. Methods This study included singletons born after 24 gestational weeks in 2017–2018 at four hospitals in Guangzhou, China. Microcephaly was defined as a head circumference at birth >3SD below the mean for sex and gestational age. Prevalence of microcephaly was estimated by binomial exact method. Multivariable logistic regression was used to examine the associations of microcephaly with prenatal factors. The population attributable fraction (PAF) for associated risk factors was calculated. Results Of 46,610 live births included, 154 (3.3, 95% CI 2.8–3.9 per 1000 live births) microcephalies were identified. Maternal hepatitis B virus carriers (HBV, OR 1.80, 95% CI 1.05–3.10) and primipara (OR 2.68, 95% CI 1.89–3.81) had higher risk of having a microcephalic baby. Higher prevalence of microcephaly was observed in women who had premature labor (OR 1.98, 95% CI 1.17–3.34) and had a baby with fetal growth restriction (OR 16.38, 95% CI 11.81–22.71). Four identified factors (HBV, primiparity, preterm labor, and fetal growth restriction) contributed to 66.4% of the risk of microcephaly. Conclusions The prevalence of microcephaly in Guangzhou was higher than expected. This study identified four prenatal risk factors that, together, contributed to two-thirds of the increased risk of microcephaly. This is the first reported association between maternal HBV carrier status and microcephaly. |
| Databáze: | OpenAIRE |
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