Diagnosis of Vulvar Lesions by Non-Invasive Optical Analysis: A Pilot Study
| Autor: | Philippe Thueler, Paolo Meda, Ilaria Dellacasa, Christian Depeursinge, Federica Capanna, Igor Charvet, Marie-Françoise Pelte, Michel Saint-Ghislain, A. T. Vlastos |
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| Rok vydání: | 2009 |
| Předmět: |
Lichen Sclerosis
Pathology medicine.medical_specialty Histology absorption spectra non invasive diagnosis lcsh:RC254-282 01 natural sciences Article 010309 optics 03 medical and health sciences 0302 clinical medicine In vivo scattering spectra 0103 physical sciences medicine 030219 obstetrics & reproductive medicine integumentary system business.industry Non invasive optical analysis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Vulvar intraepithelial neoplasia medicine.disease Gynecological Examination vulvar intraepithelial neoplasia 3. Good health VIN non invasive diagnosis optical analysis absorbtion spectra scattering spectra Oncology Vulvitis medicine.symptom business |
| Zdroj: | Rare Tumors, Vol 1 (2009) Rare Tumors, Vol 1, Iss 1, Pp e8-e8 (2009) Rare Tumors |
| ISSN: | 2036-3613 |
| DOI: | 10.4081/rt.2009.e8 |
| Popis: | A procedure that could allow an early in vivo and non-invasive detection of vulvar lesions would be extremely useful. We tested an innovative optical method (Optiprobe), which uses a harmless, visible light source for the in vivo, on-line detection of minimal alterations in the structure of vulvar epithelium. A group of 3 female volunteers without gynecological symptoms were first screened to evaluate optical properties of normal vulvar tissue. Next, a group of 16 patients undergoing gynecological examination for vulvar lesions was evaluated by the Optiprobe at suspected sites before these sites were biopsied for histological analysis. Adjacent, non-involved sites were also measured to provide internal controls. Histological analysis of the biopsies identified one case that did not show obvious alterations, 4 cases of high-grade vulvar intraepithelial neoplasia (VIN), 5 cases of vulvitis, and 6 cases of lichen sclerosis (LS). The optical properties of the VIN cases were significantly different from those of controls, due to a decrease in the absorption spectra and an increase in the scattering spectra. In contrast, a significant increase in the absorption spectra and a decrease in the scattering spectra were observed in the cases of vulvitis. In the LS cases, the absorption spectra were as in controls, whereas the scattering spectra were significantly decreased. We conclude that the Optiprobe provides a useful tool for a rapid and non-invasive detection of vulvar alterations. The method should contribute to reduce the number of biopsies and to facilitate the long-term follow-up of vulvar lesions. |
| Databáze: | OpenAIRE |
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