Prolactin-secreting pituitary adenoma in neuroleptic treated patients with psychotic disorder
| Autor: | K. Melkersson, A. L. Hulting |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Comorbidity Gastroenterology Dopamine agonist Psychoses Substance-Induced Pituitary adenoma Internal medicine medicine Haloperidol Humans Drug Interactions Pituitary Neoplasms Prolactinoma Pharmacology (medical) Clozapine Bromocriptine Biological Psychiatry business.industry Quinagolide General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Prolactin Psychiatry and Mental health Endocrinology Psychotic Disorders Dopamine Agonists Aminoquinolines Dopamine Antagonists Drug Therapy Combination Female business Antipsychotic Agents medicine.drug |
| Zdroj: | European Archives of Psychiatry and Clinical Neurosciences. 250:6-10 |
| ISSN: | 0940-1334 |
| DOI: | 10.1007/pl00007539 |
| Popis: | Three patients with psychoses and concomitant prolactin-secreting pituitary tumours are described. Patients A and B had bipolar and schizoaffective disorders, respectively. They had both been treated with neuroleptics for 20 years before the prolactinomas were revealed. Patient C developed a paranoid psychosis after two years of continuous bromocriptine treatment for a pituitary tumour. In patient A the prolactin level was successfully normalized and a good antipsychotic effect was maintained by combined therapy with haloperidol and quinagolide but not bromocriptine. In patient B the prolactinoma was removed by surgery, in view of the serious nature of the psychotic disorder, to avoid psychotic relapse by treatment with a dopamine agonist. In patient C a good result was obtained with the combination of clozapine and bromocriptine. These case reports support the view that neuroleptics being dopamine antagonists and dopamine agonistic agents which are the primary treatment of prolactinomas can cancel out each other's effects. The combination of clozapine and quinagolide is recommended as the treatment of choice for most patients. |
| Databáze: | OpenAIRE |
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