Effect of inhibition of Toll-like receptor 3 signaling on pathogenesis of rabies virus in mouse model

Autor:	Sumit Sardana, Karam Pal Singh, Mani Saminathan, Sobharani Vineetha, Shibani Panda, Murali Dinesh, Madhulina Maity, Rajat Varshney, Sourabh Sulabh, Monalisa Sahoo, Triveni Dutt
Rok vydání:	2022
Předmět:	Rabies Veterinary (miscellaneous) CD8-Positive T-Lymphocytes Toll-Like Receptor 3 Disease Models Animal Mice Infectious Diseases Rabies virus Insect Science Animals Cytokines Parasitology Copper Signal Transduction
Zdroj:	Acta tropica. 234
ISSN:	1873-6254
Popis:	Rabies is a zoonotic viral disease with inevitably fatal outcome. Toll-like receptor 3 (TLR3) could sense dsRNA viral infections, and implicated in pathogenesis of rabies and Negri bodies (NBs) formation. Present study was undertaken to elucidate the role of TLR3 in pathogenesis, NBs formation, and therapeutic potential of blocking TLR3/dsRNA interaction in rabies infection. Young Swiss albino mice were infected with 100 LD
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea281b4afaf228a66519e1f09b158618 https://pubmed.ncbi.nlm.nih.gov/35809612 Zobrazit plný text záznamu Full Text from ScienceDirect