Synthesis, crystal structure, EPR properties, and anti-convulsant activities of binuclear and mononuclear 1,10-phenanthroline and salicylate ternary copper(II) complexes
| Autor: | Bernard Viossat, Alain Tomas, John R. J. Sorenson, Pascale Lemoine, Frederick T. Greenaway, Nguyen Huy Dung, Georges Morgant |
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| Rok vydání: | 2002 |
| Předmět: |
Central Nervous System
Models Molecular Denticity Cations Divalent Stereochemistry Dimer Phenanthroline Molecular Conformation Crystal structure Crystallography X-Ray Biochemistry Medicinal chemistry law.invention Inorganic Chemistry Magnetics Mice Structure-Activity Relationship chemistry.chemical_compound law Animals Chelation Electron paramagnetic resonance Ligand Spectrophotometry Atomic Electron Spin Resonance Spectroscopy Hydrogen Bonding Salicylates Square pyramidal molecular geometry Rats chemistry Anticonvulsants Copper Phenanthrolines |
| Zdroj: | Journal of Inorganic Biochemistry. 89:18-28 |
| ISSN: | 0162-0134 |
| DOI: | 10.1016/s0162-0134(01)00324-5 |
| Popis: | Two ternary Cu(II) complexes of 1,10-phenanthroline (phen) and singly (Hsal − ) or dideprotonated (sal 2− ) salicylate ligands were synthesized, their X-ray crystal structure and electron paramagnetic resonance spectral characteristics determined, and evaluated for anti-convulsant activities in the maximal electroshock (MES) and Metrazol models of seizure and Rotorod toxicity. The X-ray crystal structure of [bis(1,10-phenanthroline)-μ-bis(salicylato-O,O′)dicopper(II)] dihydrate, 1 , {[Cu II 2 (phen) 2 (sal) 2 ]·2[H 2 O]}, shows it to be binuclear. This dimer consists of two centrosymmetrically related pseudo-five coordinate Cu(II) atoms 3.242(2) A apart and bridged by two dideprotonated salicylate ligands. The X-ray crystal structure of [bis(1,10-phenanthroline)(salicylato)copper(II)][salicylate] monohydrate, 2 , {[Cu II (phen) 2 (Hsal)] + [Hsal] − [H 2 O]}, shows it to be mononuclear. This complex cation exhibits a highly irregular distorted square pyramidal geometry about the Cu(II) atom, (4+1+1*). Each salicylate is singly deprotonated and one of them is ligand bonded in an asymmetric chelating mode. EPR results for 2 indicate that in concentrated DMF solution phen remains bonded to copper but salicylate is likely monodentate in contrast to the situation for 1 . However, in dilute DMF solution, both 1 and 2 form the same species, which accounts for the similarity in anti-convulsant activity of the two compounds. Both 1 and 2 were found to be effective in preventing MES-induced seizures and ineffective in preventing Metrazol-induced seizures. Rotorod toxicity, consistent with central nervous system depression, paralleled the observed anti-convulsant activity. It is suggested that the observed anti-convulsant activity is consistent with central nervous system depression as a physiological mechanism in overcoming MES-induced seizures due to MES-induced brain inflammatory disease. |
| Databáze: | OpenAIRE |
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