The clinical significance of autoantibodies to the proliferating cell nuclear antigen (PCNA)
Autor: | Marvin J. Fritzler, Carol L. Peebles, Kiyomitsu Miyachi, Michael Mahler |
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Rok vydání: | 2012 |
Předmět: |
Molecular Sequence Data
Immunology Autoantigens DNA polymerase delta Meta-Analysis as Topic Antigen Proliferating Cell Nuclear Antigen medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Clinical significance Amino Acid Sequence Fluorescent Antibody Technique Indirect Peptide sequence Autoantibodies Lupus erythematosus biology Autoantibody medicine.disease Proliferating cell nuclear antigen Multiprotein Complexes biology.protein Binding Sites Antibody Antibody |
Zdroj: | Autoimmunity Reviews. 11:771-775 |
ISSN: | 1568-9972 |
Popis: | Autoantibodies targeting the proliferating cell nuclear antigen (PCNA) were first described over 30 years ago and are historically most commonly associated with systemic lupus erythematosus (SLE). The primary antigenic target is a 34 kDa protein that is part of the DNA polymerase delta multi-protein complex. A number of diagnostic platforms have incorporated PCNA into their diagnostic assays and algorithms. However, little is known about the clinical utility of autoantibodies to PCNA, especially with novel detection systems. This review will focus on the history of the discovery of the PCNA autoantigen and the current status of the diagnostic significance of anti-PCNA and suggest future studies that are required to strengthen our understanding of their clinical utility. |
Databáze: | OpenAIRE |
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